The Objective Research Of Unstable Angina Pectoris Stasis-Heat Syndrome

Objective:1.To investigate the pattern of traditional Chinese medicine (TCM) syndrome differentiation in diagnosing coronary heart disease with unstable angina pectoris (CHD-UAP); and2.To assess the degree of correlation between stasis-heat syndrome in CHD-UAP and inflammatory factor IL-6, HCY, hs-CRP, and TNF-αMethod:80patients with diagnosed CHD-UAP enrolled in this study. These patients were identified from all inpatients admitted by the Cardiology Unit, Jiangsu Provincial Hospital of Traditional Chinese Medicine between April2011and February2012.1.Under the guidance of the2012Guidance Principle of Clinical Study on Traditional Chinese Medicine and the Guide to TCM syndrome differentiation and treatment of stasis-heat syndrome, the TCM syndrome differentiation for each subject was derived from the analysis of the individual’s information collected with the four diagnostic methods (see CRF Chart). The results were compiled to generate the pattern of TCM syndrome differentiation in diagnosing CHD-UAP.2.Contrastive analysis was performed to compare the degree of correlation to stasis-heat syndrome in CHD-UAP for inflammatory factor IL-6, HCY, hs-CRP, and TNF-α.SPSS was used in all analysis.Result:1. TCM clinical oberservation(1). Through the clinical observation of the80subjects,10subjects (12%) manifested the syndrome of deficiency in both qi and yin,14subjects (18%) manifested the syndrome of deficiency in yang,8subjects (10%) manifested the syndrome of yin deficiency in heart and kidney,8subjects (10%) manifested the syndrome of stagnation of yin-cold,12subjects (15%) manifested the syndrome of phlegm blocking heart vessel, and28subjects (35%) manifested the stasis-heat syndrome.(2). The stasis-heat syndrome was found to be the most prevalent syndrome differentiation for both male (45%) and female (24%). The least common syndrome differentiation in male subjects was the syndrome of yin deficiency in heart and kidney (7%), while the syndrome of deficiency in both qi and yin, deficiency in heart and kidney, and stagnation of yin-cold was the least common in female with13%prevalence each.(3). To divide by age, under40years old (inclusive), possession of the largest proportion of stasis Heat syndrome group, a total of two cases, accounting for100percent more than the case group were accounted for0%;41to50years old, it occupies the largest proportion ofthe stasis-heat syndrome group, a total of seven cases,87.5%, the smallest proportion of Qi Deficiency group, the syndrome of deficiency in yang group, heart, kidney yin deficiency syndrome group the syndrome of phlegm blocking heart vessel group, each with0%;51to60years old, occupies the largest proportion of stasis Heat syndrome group, a total of10cases, accounting for58.82percent, the smallest proportion of the syndrome of deficiency in yang group,0%each; ages61to70, it occupies the largest proportion of the syndrome of deficiency in yang group, a total of eight cases, accounting for32percent, the smallest proportion of stagnation of yin-cold group1patients (4%);71to80years old, it occupies the largest proportion of both Qi and Yin deficiency, a total of7cases accounted for25percent, the smallest proportion of is the syndrome of phlegm blocking heart vessel group and stasis heat Competing card group, each with three cases,3%each.2. The relationship between each group and related inflammatory factors(1) To compare hs-CRP among the three groups, stagnation of yin-cold group and the syndrome of phlegm blocking heart vessel group have no significant difference (p=0.075), there were significant differences between the other groups (p<0.01); HCY among the three groups are significant different among the groups (p<0.01); IL-6in each group between the group of heart yin deficiency and stagnation of yin-cold group have no significant difference (p=0.101), There was no significant difference between heart yin deficiency group and the syndrome of phlegm blocking heart vessel group(p=0.113). The stagnation of yin-cold group with the syndrome of phlegm blocking heart vessel group have no significant difference (p=0.827), The stagnation of yin-cold group and Stagnant Heat group have no significant difference (p=0.303), phlegm systolic group stasis Heat syndrome groups have no significant difference (p=.140), other groups were significantly different (p<0.01); To compare TNF-a among the three groups, the stagnation of yin-cold group and the syndrome of phlegm blocking heart vessel group are without significant difference (p=0.927), there were significant differences among other groups (p<0.01).(2) Stagnant-heat syndrome group compared with hs-CRP and other group of HCY, IL-6and TNF-alpha, has a significant difference (p<0.01).Conclusion:(1) The80collected cases of unstable angina patients, the highest proportion is the stasis-heat syndrome group, then it is the syndrome of deficiency in yang, followed by the syndrome of phlegm blocking heart vessel, followed by the syndrome of yin deficiency in heart and kidney which has the same proportion with the syndrome of deficiency in yang.(2) Among the collected cases, the male patient with stasis-heat syndrome occupies a ratio greater than female patients. The proportion of the patient with unstable angina Stagnant Heat syndrome who are under70years of age (inclusive) is significantly higher than those over the age of70.(3) HCY group comparative analysis has the significant differences (p<0.01), no significant difference among hs-CRP, IL-6, TNF-alpha comparative analysis.There is a significant difference among petechia Heat syndromegroup,hs-CRP and other group of HCY, IL-6and TNF-alpha (p<0.01)...