Effect Of Tanshinone Injection On Myocardial Reperfusion Injury And Different Style Of TCM

Objective:To evaluate the effect of tanshinone injection on myocardial reperfusion injury and possible mechanism.Methods:92patients with percutaneous coronary intervention (PCI) were randomly divided into control group (n=20), drug treatment group(n=36) and tanshinone group (n=36, and divided into the empirical22cases and deficiency syndromes14cases). Compared the changes of inflammatory cytokines (IL-6, IL-10, TNF-α and oxidative stress factors (SOD, MDA), NO before surgery with24hours and7days after surgery.Results:Compared the24hours after PCI with the pre-operation, the level of inflammatory cytokines(IL-6and TNF-α increased, IL-10declined) and oxidative stress factors (SOD declined, MDA increased) and NO were changed significantly (P<0.05). The inflammatory cytokines (IL-6, IL-10, TNF-α) and oxidative stress factors (SOD, MDA)and NO of drug treatment and tanshinone groups,7days after, were better than control group. The level of inflammatory cytokines (IL-6, IL-10, TNF-α) and oxidative stress factors (SOD, MDA) and NO were no difference between tanshinone group and drugs treatment group(F>0.05). The level of inflammatory cytokines (IL-6, IL-10, TNF-α) and oxidative stress factors (SOD, MDA) and NO of the empirical syndrome group, treated by tanshinone7days after PCI, were better than deficiency group(but P>0.05).Conclusion:Tanshinone injection has a protective effect on myocardial reperfusion injury; the mechanism may be related with which can regulate the level of inflammatory cytokines and oxidative stress factors; Tanshinone injection has better effect on the patients who will undergo PCI with empirical syndrome of TCM.