| Research purposes:This study through the observation, the evaluation of patients with clinical index (pain joint swelling of the joints, the number of number, HAQ index, etc), biochemical index (rheumatoid factor (RF), blood sedimentation (ESR), c-reactive protein (CRP)), Curative effect evaluation (disease curative effect evaluation, disease activity evaluation), and other changes, Evaluation of far row needles subcutaneous lien method many drugs to active rheumatoid arthritis (RA) the curative effect of the advantages and security.Research methods:66patients with active RA patients, according to the age, sex, functional status paired off and, by means of random distribution mode into pure envelope drug group (33cases) and needle medicine joint group (33cases) two groups (the\"drug group and needle respectively medicine group). Remove eliminate and loose cases, finally complete drug group (31cases), needle medicine group32cases. Take treatment:(1) drug group:methotrexate piece of10mg once a week, fill to yesterday cloth capsule (celebrex)200mg once per day, the illness serious when plug to yesterday cloth capsule increased to200mg twice daily, with illness adjustment dose.(2) the needle treatment group:in the drug group the foundation of treatment combined with far department row needles subcutaneous lien method--with HaoZhen, according to the lesion site (press lesions, according to the joint pain, follow the range of small area is close, big range spot of MTRPS should be far more, the principle that the two joint between a third in the range) the needle selection point, the needle with a15°body skin along the skin quickly penetrate into the subcutaneous shallow fascia layer, and then to focus points needle direction slowly push the, again make needle (a) travel needle back and forth about30times, need not (acid hemp pain, etc) needle feeling. Every two needle into the point about8mm intervals. With the intravenous infusion fixed the stick pins handle, LiuZhen24h. Every time are in the needle1hour, take to press the observation after sickness point operation. Row thorn region from far to close, and avoid the needle points at the same position in a straight line or stimulated repeatedly. Once a day, five times a week/1treatment treatment, were the treatment of three treatments (20days).In treatment, before and after the two groups of clinical observation index (joint swelling number, tenderness joint number, morning stiffness time, grip,20m hands on foot time, HAQ index, the evaluation, patients to pain patients to illness of the comprehensive evaluation of the illness and the doctor comprehensive evaluation), detection biochemical index (RF, ESR, CRP). During the course of treatment for the first time after the treatment of patients with records of the evaluation of the pain, dynamic observation effect to time and in the course of treatment adverse reactions. Using the American rheumatism learn to rheumatoid arthritis diagnosis standard (ACR20),28joint disease activity score (DAS28) efficacy evaluation, SPSS17.0application software in statistical analysis.The results:1. Clinical index:after the first treatment of pain assessment and the improvement of the work time, needle medicine group is obviously superior to drug group, has a statistically significant difference (P﹤0.01). Before and after the treatment of their own contrast, two groups of all the indexes have improved. After treatment, the two groups of the two halves: patients on the comprehensive evaluation and the doctor illness to the improvement of the comprehensive evaluation of the illness, the needle with drug treatment group than group has obviously improved, have a statistically significant difference (P﹤0.01); Joint swelling number, tenderness joint pain, the number of evaluation, morning stiffness time, both hands,20meters walking grip the improvement of the time, the two groups have a statistics difference (P﹤0.05); HAQ index is no statistical difference between the two groups (P﹥0.05);2. Biochemical indicators:needle medicine group to RF and ESR improvement, the group is obviously better than drugs, have a statistics difference (P﹤0.05). But CRP two groups of no difference (P﹥0.05).3. The evaluation of clinical curative effect: after treatment, DAS28scores (disease mobility evaluation), two groups of statistically significant (P﹤0.05). ACR curative effect evaluation (disease outcomes assessment), two groups of statistically significant (P﹤0.05). One needle treatment group has reached ACR2011cases,18cases of ACR50,2cases of ACR70; Drug group has reached ACR2014cases,8cases of ACR50,1case of ACR70,4. Safety assessment: treatment group after treatment, the needle digestive tract of discomfort happened obviously less than average drug group, has a statistically significant difference (P﹤0.01).5. Taking non-steroidal anti-inflammatory drugs (NSAIDs): after treatment, the needle medicine group stop taking NSAIDs number significantly more than drug group, has a statistically significant difference (P﹤0.05). One needle medicine group stop taking of29), drug group stop taking several only for6patients.Conclusion:1. The joint and needle medicine only with drugs are effective active RA; 2. Needle medicine to improve the clinical symptoms, the joint clinical index and biochemical indicators are better than simple drugs;3. Needle medicine with pain, joint fast effect to the advantage of short time;4. Needle medicine can reduce joint dosage of western medicine;5. Needle medicine can reduce RA joint adverse reaction of western medicine therapy;6. Needle medicine treatment of joint is active RA safe and effective method. |
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