Clinical Observation On The Treatment Of Rheumatoid Arthritis With Cold And Dampness Syndrome By Acupoint Application Combined With Western Medicine

OBJECTIVE:Rheumatoid arthritis(RA)is a chronic symmetrical autoimmune disease.This study mainly through clinical randomized controlled trials,observation of the experimental group and the control group Treatment.Patients with pre-treatment DAS28 scores and changes in clinical symptoms,laboratory indicators and other related indicators to assess the clinical efficacy of acupoint sticking combined with Western medicine.METHODS:Seventy subjects who met the inclusion criteria were randomly divided into the experimental group and the control group.35 patients in each group were treated with methotrexate,folic acid tablets,leflunomide tablets,meloxicam,and the experimental group was given orally.Add acupuncture points to the drug.Acupoint sticks are applied once a week for 4 weeks for a course of treatment,for a total of 2 courses.Observe the laboratory indicators,main clinical symptoms,TCM syndrome scores,and changes in Das28 before and after treatment.Laboratory indicators include ESR,CRP,RF;clinical symptoms include joint tenderness,joint swelling,average hand grip strength,morning stiffness duration,pain VAS score five;TCM syndrome scores(main card: joint pain,swelling,morning Stiffness,tenderness,cold joints,unfavorable flexion and extension,and sub-certification: mouth is not thirsty,cold and cold,and heavy limbs;disease activity was evaluated using DAS28 score.Closely observe the adverse reactions during the treatment,conduct safety evaluation and record truthfully.After the end of the experiment,data statistics were performed to evaluate the efficacy.Results:1.During the test,four cases were detached,including tow cases in the test group and tow cases in the control group.Sixty and six cases were finally completed,including fifteen males and fifty one females,and the females were significantly more than males.2.Before and after comparison in the group:There was no significant difference between the two groups(sex,age,duration of disease,clinical symptoms,DAS28 score,laboratory index,TCM syndrome score)(p>0.05),and the baseline was comparable.3.Comparison between groups:The clinical symptoms and signs,laboratory parameters and DAS28 scores of the two groups were significantly different after treatment(p<0.05).The two groups of treatments improved the above indicators;The difference between the groups was statistically significant(p<0.05).The treatment group was better than the control group.4.The total effective rate of the treatment group was 87.88%;the total effective rate of the control group was 75.76%,the difference was statistically significant(p<0.05).The total effective rate of TCM syndromes in the treatment group was 81.81%;the total effective rate of TCM syndromes in the control group was 66.67%,the difference was statistically significant(p<0.05).Comparison of TCM Syndrome Points:In the improvement of TCM symptoms such as cold joint,unfavorable flexion and extension,chills and heavy limbs,the control group was worse than the treatment group(p<0.05).There were no significant remissions in the two groups.There was no significant difference between the two groups(p>0.05).5.The incidence of adverse reactions in the treatment group was 9.09%,and the incidence of adverse reactions in the control group was 6.06%.There was no significant difference in the incidence of adverse reactions between the two groups(p>0.05).In conclusion:1.The two groups of treatment methods have good clinical curative effect on the treatment of cold dampness and stasis type RA.The effect of acupoint sticking combined with western medicine treatment group is better than that of pure western medicine alone.2.The experimental group can improve the clinical symptoms of patients,reduce laboratory indicators(ESR,CRP,RF),reduce the patient’s disease activity(DAS28 score)and TCM syndrome total score,have certain safety,patient compliance,clinical operation is simple.It is worth further research.