Clinical Observation Of Using Pennisetum Lotion In The Treatment Of Leg Wound Combined Pseudomonas Aeruginosa Speciality:Orthopedics Of Traditional Chinese Medicine

ObjectiveThe objective of this study is to analyze the clinical effects of using Pennisetum lotion(Pulsatilla and Prunella lotion) in the Treatment Of leg wound combined Pseudomonas aeruginosa,through testing and observing the clinical effects, Data processing. To Provide an effective treatment for leg Pseudomonas aeruginosa wound infection for the clinical, shorten treatment time and reduce the recurrence rate of infection.MethodsThrough modeling50SD rats Skin defects and wound combined with Pseudomonas aeruginosa infection,Then randomly divided into5groups (n=10), were Pennisetum lotion, gentamicin sulfate, Pulsatilla lotion, Prunella vulgaris lotion, sterile Vaseline gauze and topical wound, After the modeling and1d,3d,5d,9d,14d observated the wound exudate, granulation growth, wound healing, determinate area in section3d,5d,9d,14d, and determinated wound tissue bacterial quantitative in the section of3d,5d,9d,14d of. Did The wound’s pathological examination in14days and observed the growth of macrophages. A random control design of clinical trials was adopted. The60Patients whose leg wound combined Pseudomonas aeruginosawere divided into two groups randomly,and observated tThe wound healing rate, growth of granulation, Wound exudate fluid, detection of bacteria.ResultsAnalysised and processed the size of wound infection, bacterial counts by SPSS17.0software package for data, the results using the mean standard deviation (χ±s), between groups using analysis of variance. Amount of wound exudate, the growth of granulation was statisticsed by Rank sum test of ranked data,if the results is P<0.05, Statistically significant results are meaningful. Animal experiments showed that the Pennisetum lotion group in wound size were significant difference from gentamicin sulfate group, Pulsatilla Decoction group, Prunella vulgaris decoction group, sterile vaseline gauze group (P<0.01=. Observed Pseudomonas aeruginosa wound infection, granulation growth of Pennisetum lotion group, significantly reduced exudate, wound narrowed, color was bright red. The pathological results showed that There were a large number of macrophages present in the wound infected by Pseudomonas aeruginosa of the Pennisetum lotion group. Two SD rats of Vaseline gauze group were died7days, Two groups of patients with wound healing rate compared with their own t test, the differences were highly significant (P<0.05) significance. Clinical evaluation, in the treatment group the total effective rate was93.3%, effective rate is66.67%; in the control group total effective rate was80%, effective rate is33.33%. Compared with Ridit test, the treatment group and the control group compared with significant difference (P<0.05), results showed that the treatment group than control group.ConclusionThe Pennisetum lotion treatment of leg Pseudomonas aeruginosa infection of the wound effect was significant, and significantly better than that of the efficacy of gentamicin sulfate group. This was a safe and effective traditional Chinese medicine treatment of leg Pseudomonas aeruginosa wound infection.