Clinical Study On Intervention Of Deng’s Corocardial Decoction On Coronary Heart Disease Patients After PCI

ObjectivesIn this study, through the grouping by the PCI after Integrative Medicine treatment (plus service Deng’s Corocardial Decoction), clinical observation of the purely Western drug intervention to relieve symptoms of angina, quality of life, the comparison of postoperative adverse cardiovascular events. TCM symptoms, lipids and other related indicators change analysis, evaluation Deng old Guanxin capsule to explore the therapeutic effect of single lesions in the coronary heart disease by after PCI.MethodsResearch for Guangdong Provincial Hospital Heart Center since October2009to March2012,120cases met the inclusion criteria after PCI with coronary heart disease patients, a randomized controlled. The patients were divided into treatment group and control in accordance with3:1group, and coronary angiography in the treatment group patients were divided into treatment group (LAD), treatment group2(LCX), and treatment group3(RCA);the group of patients in age, sex, risk factors, type of disease, surgery information and concomitant medications, the difference was not statistically significant and comparable. In each group follow the guide asked for after PCI conventional western medicine, including aspirin100mg qd, clopidogrel75mg qd, Lipitor20mg qn, oral; treatment group on the basis of this Deng’s Corocardial Decoction three tid oral treatment for three monhs. Selected cases associated with other diseases, such as hypertension, diabetes, etc., reference to domestic guide to the appropriate medication. Re-admitted for recurrent angina, TCM Therapeutic Evaluation scoring postoperative adverse cardiovascular events, lipids four (CHOL, TG, LDL-C HDL-C) were observed. ResultsAfter3months of treatment, cardiovascular events in the treatment group and control group, the incidence of6.74%and16.7%, the difference was statistically significant (P<0.05); treatment group, the number of angina pectoris time, pain, angina score significantly better than the control group, a statistically significant difference (P<0.05); the three treatment groups before treatment difference between groups was not statistically significant (P>0.05) in each group before and after treatment angina attack frequency and pain frequency and pain duration were improved (P<0.05), significant improvement in angina extent than before treatment, angina count in the same group of sub-before and after treatment was statistically significant (P <0.05); treatment group1degree of pain, angina score decreased compared with the other two groups decreased significantly (P<0.01).Treatment group compared with the control group, pre-treatment lipid indicators were no significant differences (P>0.05). After treatment, the TC, LDL-C compared with pre-treatment decreased significantly difference was statistically significant (P<0.05), the treatment group between the two groups of TC, LDL-C were lower than the control group, a statistically significant difference (P<0.05); two groups of TG were lower than before treatment, the difference was statistically significant (P<0.05); two groups of HDL-C than those before treatment increased slightly, but not statistically significant (P>0.05). Compare differences between the three treatment groups before treatment group was not statistically significant (P>0.05) in each group before and after treatment of TC, LDL-C decreased significantly (P<0.05), the same group of TC, LDL-C treatment before and after statistically significant (P<0.05); treatment group1decreased significantly (P<0.01) than the other two groups fell.Safety monitoring shows that each group of blood, urine and stool, liver and kidney function before treatment, compared to roughly the same, and found no deterioration, indicating that Deng’s Corocardial Decoction has good security, no significant or serious adverse reactions.ConclusionsDeng’s Corocardial Decoction can be effective in reducing coronary heart disease alone lesion after PCI, particularly the left anterior descending artery lesions in angina recurrence, relieve symptoms and improve lipid metabolism, reducing low-density lipoprotein (LDL-C) from the overall on the intervention of coronary artery disease single-lesion PCI after surgery, thereby improving after PCI in patients with clinical conditions, and no obvious toxic side effects.