Meta-analysis Of Traditional Chinese And Western Treatment On Ulcerative Colitis

Objective: Ulcerative Colitis(UC) is a kind of chronic non-specific inflammatory bowel disease, in rectum and colon,which is in a gradually growing trend in our country,and its etiology is still unclear.In recent years,traditional Chinese medicine with Western medicine have been being taking in clinical treatments, which has been received good results.According to the based-evidence medicine theory,in the collection of abundant clinical reseach on this disease,attempt to apply Meta-analysis statistical methods to obtain a comprehensive and objective evaluation in the treatment of ulcerative colitis, and evaluate wether Western medicine combined traditional Chinese medicine therapy more advantageous than simple Western medicine therapy.Method:Applicatingof a computer system to retrieve the Chines and English databases, including PUBMED、MEDLINE、EMBASE、ELSEVIER SCIENCE、CNKI、VIP、Wanfang database,and ask authors the necessary information to collect relevant literature, combined with manual searches and literature retrospective approaches.Formulate the literature inclusion criteria, collect literature and evaluate the quality of the literature included independently by three researchers, extract the basic information and data from the literature,make heterogeneity test in each study group and affiliate the statistics,obtain the results, estimate wether there is bias among the results in use of funnel plots,make sensitivity analysis with methods of conversing effect model and excluding the maximum and minimum weight.Applying software Revman5.1provided by Cochrane Collaboration to accomplish the statistical procedures.Results: A total of16pieces of research papers are carried out by Meta-analysis in this article,including1019cases in the treatment group and878cases in the control group.The results show that,there is statistical difference between treatment group and control group in the clinical efficacy,P<0.00001,OR4.51,95%CI [3.29,6.18];there is statistical difference between treatment group and control group in the improvement of the intestinal mucosal lesions,P<0.00001,OR11.76,95%CI [4.15,33.3];there is statistical difference between treatment group and control group in the improvement of the intestinal mucosa congestion and edema,P=0.001,OR20.13,95%CI [3.29,123.28];there is statistical difference between treatment group and control group in the improvement of the intestinal mucosa ulcer,P<0.00001,OR15.16,95%CI [8.07,28.45];there is statistical difference between treatment group and control group in the improvement of the intestinal mucosa erosion,P<0.00001,OR16.53,95%CI [7.45,36.66];there is statistical difference between treatment group and control group in the improvement of abdominal pain and diarrhea symptoms,P=0.002,OR7.86,95%CI [2.08,29.76];there is statistical difference between treatment group and control group in the improvement of bloody purulent stool symptom,P<0.0001,OR8.20,95%CI [3.21,20.97];there is statistical difference between treatment group and control group in the improvement of tenesmus symptom,P=0.004,OR15.84,95%CI [2.44,102.94];there is statistical difference between treatment group and control group in the disease activity index score,P=0.003,MD-0.71,95%CI [-1.71,-0.24];there is no statistical difference between treatment group and control group in the disease score of immunological parameters IgQP=0.15,MD-1.97,95%CI [-4.63,0.96];there is statistical difference between treatment group and control group in the disease score of immunological parameters IgM,P=0.02,MD-0.90,95%CI [-1.65,-0.16];there is no statistical difference between treatment group and control group in the disease score of immunological parameters IgA,P=0.06,MD-1.02,95%CI [-2.09,0.04];there is no statistical difference between treatment group and control group in the disease score of whole blood viscocity,P=0.16,MD-1.03,95%CI [-2.47,0.42];there is statistical difference between treatment group and control group in the disease score of plasma viscocity,P<0.00001,MD-0.36,95%CI [-0.44,-0.28];there is statistical difference between treatment group and control group in the disease score of erythrocyte sedimentation,P=0.001,MD-7.84,95%CI [-12.61,-3.07].ConclusionrWestern medicine combined traditional Chinese medicine therapy are more advantageous than simple Western medicine therapy in the following directions:the overall clinical efficacy,the disease activity index score,the score of immunological parameter IgM,the score of whole blood viscocity and erythrocyte sedimentation,the improvement of the intestinal mucosal lesions,the improvement of intestinal mucosa congestion and edema、 intestinal mucosa ulcer、intestinal mucosa erosion and the improvement of bdominal pain and diarrhea symptoms、 bloody purulent stool symptom、tenesmus symptom. But it is uncertain that wether Western medicine combined traditional Chinese medicine therapy more advantageous than simple Western medicine therapy in the following directions:the score of immunological parameters IgG、IgA, the score of blood rheological parameter whole blood viscocity. And the result of the score in immunological parameter IgG maybe not reliable.