Small For Gestational Age Infants Plasma Visfatin Levels And Its Clinical Significance

Small for gestational age infants in the neonatal period to hypoglycemia, respiratory distress,necrotizing enterocolitis, to adult period prone to metabolic syndrome, including hyperglycemia,hypertension, hyperlipidemia and obesity, so many scholars attention. This paper explores theplasma visfatin levels and intrauterine fetal growth correlation, thereby from fetalgrowth and development of small for gestational age occurrence mechanism, will helpus to further improve the quality of the birth population, prevention of adult diseases,put forward a new research direction.Object and method1.study object: all the subjects were from the province of Shanxi children’s Hospitalin 2010February ~2010October neonatal inpatients. According to China’s15city inneonates with different gestational age and birth weight value and percentile(1986-1987) table is divided into SGA group and AGA group, two groups of pregnantZhou Man 37 weeks less than 42 weeks, with the exception of the pregnant motherpregnant high disease, endocrine diseases, infectious diseases, placenta and umbilicalcord abnormalities, and all be eutocia neonatal, no intrauterine distress and after birthasphyxia and other complications. That was only a mild aspiration, swallow syndromeof newborn.2.methods：two groups of neonates in day old 0-3days,7-10days respectively adoptits fasting venous blood, in sodium citrate in the tube (immediate shake ), roomtemperature and set aside for 30 minutes, and then in the1000 x g under conditions ofcentrifugal5 minutes, collect the plasma, a20 DEG C refrigerator. Application ofELISA method in determination of plasma visfatin concentrations ( sensitivity of1.0ng / ml ), insulin concentration (1.0mIU / ml sensitivity ), kit from the Shanghaiblue base biological technology limited.3.Application of statistical analysis method , SPSS13 statistical software package forstatistical analysis, all the measurement data to mean + SD ( + s) representation, data analysis using t test, correlation analysis correlation with Pearson, P <0.05, withstatistical significance.Results1. group SGA0-3day visfatin levels were significantly higher than those inAGA group ( t = 4.515, P < 0.05), group SGA7-10 day of visfatin levels were alsosignificantly higher than that of AGA group ( t = 9.534, P < 0.05), SGAgroup0-3and7-10visfatin levels have no significant difference ( t = 0.7, P > 0.05),AGA group0-3and7-10visfatin levels have no significant difference ( t = 1.399, P >0.05).2. The Correlation Analysis by Pearson correlation analysis, group AGA0-3day of visfatin and insulin levels were not significantly correlated ( r = 0.315, P >0.05), SGA group0-3 day of visfatin and insulin levels have no significant correlation( r = 0.289, P > 0.05). Group AGA7-10 day of visfatin levels and insulin levels werenot significantly correlated ( r = 0.054, P > 0.05), SGA group7-10 day of visfatinlevels and insulin levels were not significantly correlated ( r = 0.191, P > 0.05).ConclusionIn the present study, compared with AGA, group SGA visfatin levels areincreased , insulin levels are reduced, thus visfatin may be involved in the intrauterinegrowth process, and has certain relation with occurrence and development of small forgestational age infants . This study also found that the concetrations between groupsof visfatin and insulin on average have no significant correlations, and thus cannot beconfirmed visfatin and insulin, namely the regulation of fetal and neonatal growth anddevelopment of the" glucose - insulin - IGF-1" relationship between the axis, morecannot confirm visfatin by insulin regulation, its involvement in the fetus intrauterinegrowth process may be another mechanism, need to be further discussed.