Effect Of Tongfu Xiere Method On Sepsis-induced Acute Lung Injury And Protective

Sepsis is a severe infection, severe trauma, severe acute abdomen, large operation after surgical critical illness often accompanied by complications, is also induced by septic shock, multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF). Main reason. Epidemiological study showed that, in recent years the incidence of sepsis has continued to rise, and the case fatality rate can not be cut down, on human health has posed the serious threat. The lungs are the sepsis is most susceptible to damage in target organs, acute lung injury (ALI) appeared at the earliest stage, and a higher rate of (1,2). Acute lung injury is a variety of pulmonary and causative factors leading to intractable hypoxemia and respiratory distress for the characteristics of the systemic inflammatory response syndrome, and acute lung injury common etiology with sepsis, trauma, shock, sepsis is the most common etiology. Although the sepsis and sepsis induced lung damage recognition and diagnosis treatment has made considerable progress, but the effect is not exact, and the combination of traditional Chinese and Western medicine treatment is the treatment of sepsis and acute lung injury and other complications are important measures. Combination of Chinese traditional and Western Medicine on TCM syndrome differentiation combined with microscopic pathological changes, in the treatment of sepsis and flexible processing, for the treatment of sepsis has provided a new way④ObjectiveThrough animal experimental observation on effect of Tongfu Xiere Decoction on sepsis-induced acute lung injury, the exploration of Chinese "a fundamental solution, anxious under save Yin" therapeutic principle of principle, for the research and development of traditional Chinese medicine new technology in the treatment of sepsis to provide scientific theoretical basis.MethodsTo establish a rat model of sepsis. To the filling effect of Tongfu Xiere Recipe. Selection of cleaning SD rats were randomly divided into6groups (n=20):normal control group, model control group, model group, saline control model of traditional Chinese medicine in low dose group (1g/ml), the model of traditional Chinese medicine in low dose group (2G/ml), the model of traditional Chinese medicine in low dose group (4G/ml). To observe the effects of different concentrations of Tong-Fu-Xie-Re medicine on sepsis rats blood endotoxin, procalcitonin, blood gas analysis, histopathological and immunohistochemical changes.AchievementsTong-Fu-Xie-Re prescription can significantly reduce sepsis rat arterial blood PaC02value, improve sepsis rat arterial blood Pa02and pH value, and significantly reduce Sepsis Rats Pulmonary micro vascular endothelial cell injury, ease due to sepsis caused by pulmonary edema, decreased alveolar and capillary bronchial inflammation exudative, improve lung inflammatory pathological changes.ConclusionTong-Fu-Xie-Re medicine on sepsis induced acute lung injury has a protective effect.