Etiologic Analysis Of Acute Respirator Tract Infection In Children

Objective:To investigate the pathogen spectrum with acute respiratory infection in children, which conduct how to use antibiotics and decrease the progress of drug resistance.Methods:997hospitalized pediatric patients with acute respiartory tract infection were analyzed in the Department of Pediatrics of First Hospital of Lanzhou University from Jan.2008to Dec.2010. Sterile specimens from respiratory secretions, conduct conventional bacterial culture and in vitro susceptibility testing, monitor viral pathogen, analysis of the pathogenic spectrum of acute respiratory infections of children in Lanzhou Region, and summarize the pathogen composition and resistance. Results:Among the997cases,we cultivated498bacteria of425samples,the detection rate is42.73%.There were151Gram Positive Bacteria(30.32%),319Gram Negative Bacteria(64.06%). Shared the majority proportion bacteria were SP83(16.7%), Ecoli83(16.7%), K.pn56(11.2%), HI59(11.8%),SA59(11.8%), HPI51(10.2%) and PA9(1.8%).All these bacteria except PA had statistically significant difference in detection rate between different age groups and clinical diagnostic groups.The resistance phenotype of SA, E.coli and HPI in detection rate had significant difference in each year and the highest detection rate was in2009. The rate of total virus detection was70.92%ranking top three were RSV(30.77%), HRV(15.61%),PIV(10.76%). There were statistically significant in bacteria and virus decetion rate between different age groups.With the increasing of age,the detection rate trended to decline.Among all these997cases,6.92%specimens were bacteria co-infected,19.56%specimens were virus co-infected and10.73%were both bacteria and virus co-infected. SP and SA were most sensitive to linezolid and vancomycin. E.coli and K.pn were most sensitive to carbapenems.HI and HPI were relatively sensitive to common antibiotics. Conclusion:In the past three years, acute respiratory tract infection pathogens mainly to the virus and followed by bacteria in Lanzhou. Under3years age group have the highest morbidity. RSV was the highest dection rate virus.Among the bacteria,SP and E.coli was the most,flowed by SA,HI,K.pn,and HPI.These bacteria had statistically signifeicant difference in dectection rate between different age groups and clinical diagnostic groups. SP and SA were most sensitive to vancomnycin and linezolid. E.coli and K.pn were most sensitive to carbapenems.HI and HPI were relatively sensitive to common antibiotics. So clinical doctors should use antibiotics based on the microorganism cultivation and sensitivity test in order to decrease the emerging of drugresistance strain.