Antibiotic Susceptibility Of Clinical Isolates From Lower Respiratory Tract Infection Patients And Study On The Importance Of Bacteria Culture

Objective:To investigate the distribution of infectious pathogenic bacteria oflower respiratory tract infection in respiratory department and to analyzethe drug resistance of the pathogenic bacteria. We also investigate theaccuracy of the initial therapy, the clinical value of bacteria culture inorder to provide a scientific basis for choosing appropriate antibiotics forthe patients who suffer from lower respiratory tract infection.Methods:In this reach, sputum, broncho-alveolar lavage fluid, puncture fluidand blood samples from1923lower respiratory tract infection patients of2011in our hospital have been analyzed.Also, the clinical data of the patients who suffer from Klebsiellapneumoniae, Pseudomonas Aeruginosa or Aspergillosis infection wereretrospective reviewed. We study on the accuracy of the initial therapy.Results:1.1441of the1923patients had different kinds of bacteria culture,the rate of sampling was74.9%. Removal of the same patients repeatedlycultured same stains,cultiwate a total of579stains of pathogenicbacteria,the separation rate was40.2%.2.Gram-negative bacteria is the majority strains of bacteria,and thetop five of them are Klebsiella pneumoniae, Pseudomonas aeruginosa,Baumanii, Pseudomonas maltophilia, Colon bacillus. The most common species of Gram-positive bacteria are Staphylococcus aureus,Streptococcus pneumoniae. Candida is still the majority strains of fungus.3.In our research, Klebsiella pneumoniae have a low drug resistanceto common antibiotics. There is no Klebsiella pneumoniae resistant toImipenem, Cefoperazone/Sulbactam and Piperacillin/Tazobactam. Lessthan10%of Escherichia coli have a resistant to Imipenem, Amikacin andCefoperazone/Sulbactam,;but more than70%of them resistant toCiprofloxacin. Less than10%of Pseudomonas aeruginosa have aresistant to Cefoperazone/Sulbactam, Amikacin, Tobramycin andLevofloxacin; but the resistance to Imipenem was16.7%. The resistanceto Minocycline and Cefoperazone/Sulbactam of Baumanii were less than15%; the resistance to Imipenem was34.3%. there are no resistance toVancomycin and linezolid of Staphylococcus aureus.4.The cases which had Klebsiella pneumoniae, PseudomonasAeruginosa or Aspergillosis were retrospectively analyzed on theaccuracy of the initial therapy, the improvement of the patients and thebacteria removal in order to determine the possibility that they are thereally causes of the disease. Through the reaserch, we consider91.5%ofKlebsiella pneumoniae,55.8%of Pseudomonas Aeruginosa and28.6%ofAspergillosis are the really causes of the lower respiratory tract infection.Conclusion:1.The main pathogen of lower respiratory tract infection in ourdepartment is Gram-negative bacteria, and these bacteria have lowresistant to Imipenem, Cefoperazone/Sulbactam, Piperacillin/Tazobactamand Amikacin. Gram-positive bacteria have no resistant to Vancomycinand linezolid.2.When Klebsiella pneumoniae were cultured from patients whosuffered from lower respiratory tract infection drug should be adjusted according to the drug test. However,when Pseudomonas Aeruginosa andAspergillosis were cultured from patients who suffered from lowerrespiratory tract infection,the treatment to them should be carefullycarried out based on more effects.