Antibiotic Associated Diarrhea In Patients With Septic Shock:A Clinical Analysis

Objective:To study the clinical features of antibiotic-associated diarrhea(AAD) in patients with septic shock and its related factors in order to reduce its incidence.Methods:The341patients with septic shock admitted to the ICU of our hospital from Jan2004to Dec2010were retrospectively studied by single factor and logistic regression analysis, and90of341were found with antibiotic-associated diarrhea (26.39%).Results: Incidence of AAD in patients with septic shock was26.39%, higher than that of inpatients at the corresponding time,which was7.8%. By the single factor analysis, AAD in patients with septic shock was correlated with ages, APACHE Ⅱ score, fasting time, plasma level of albumin, combination of antibiotics, using of glucocorticoid or alanyl-glutamine dipeptide, but sex. By logistic regression analysis and sorted by size of OR, the risk factors of AAD in patients with septic shock were fasting time, time consumed with mean arterial blood pressure (MAP) reaching65mmHg,combination of antibiotics, plasma level of albumin, APACHE Ⅱ score,but ages and using of glucocorticoid did not significantly relate to it. Using of alanyl-glutamine dipeptide was the the protective factor of the AAD in patients with septic shockConclusion:AAD in patients with septic shock had their own characters which clinicians should pay more attention to. Patients with septic shock were more susceptible to AAD than other patients. The risk factors of AAD in patients with septic shock were fasting time, time consumed with mean arterial blood pressure (MAP) reaching65mmHg,combination of antibiotics, plasma level of albumin, APACHE Ⅱ score,but ages and using of glucocorticoid did not significantly relate to it.Antishock, early enteral nutrition, rational use of antibiotics and appropriate use of alanyl-glutamine dipeptide to patients with septic shock might reduce its incidence.