Changes In Heparin-binding Protein,procalcitonin,and C-reactive Protein Within The First 72 Hours Predict 28-day Mortality In Patients Admitted To The Intensive Care Unit With Septic Shock

Background:Aimed to evaluate heparin-binding protein(HBP),procalcitonin(PCT),and C-reactive protein(CRP)levels as factors associated with 28-day mortality in septic shock patients admitted to Intensive Care Unit(ICU).Material and Methods:Blood samples were taken and measured again 72 hours after ICU admission to calculate changes in HBP(ΔHBP),changes in PCT(ΔPCT),changes in CRP(ΔCRP),and changes in Sequential Organ Failure Assessment(ΔSOFA)relative to baseline.Results:Variables included in the univariable logistic regression model for survival were age,Acute Physiology and Chronic Health Evaluation(APACHE)II scores,decreasing?SOFA,decreasing ?HBP,decreasing ?PCT,and decreasing ?CRP.Survival was directly related to decreasing ?HBP with odds ratio(OR)= 9.95(95% confidence interval[CI] 4.63 to 21.35;P<0.001),decreasing ?PCT with OR = 7.85(3.74 to 16.49;P<0.001),decreasing ?CRP with OR = 5.83(2.84 to 11.97;P<0.001),decreasing ?SOFA with OR= 1.93(1.00 to 3.75;P=0.051)and APACHE II with OR = 1.39(1.14 to 1.68;P = 0.001).In a multivariable logistic regression model for survival,only decreasing ?HBP with OR= 7.18(2.91 to 17.69;P<0.001),decreasing ?PCT with OR = 5.17(2.12 to 12.56;P<0.001),and decreasing ?CRP with OR = 4.33(1.77 to 10.61;P = 0.001)remained significant.Conclusions:Measuring changes in HBP,PCT,and CRP within 72 h of admission may aid in predicting28-day mortality for patients in ICUs suffering from septic shock.