The Expression And Significance Of Psoriasin In Lichen Planus And Acute Febrile Neutrophilic Dermatosis

Psoriasin was originally discovered in the lesions of patients with psoriasisin1991, and was identified as a member protein of S100family. Previousstudies have shown that psoriasin was extensively expressed in inflammatoryskin diseases with scales, such as atopic dermatitis and mycosis fungoides, aswell as in skin tumors. Psoriasin is involved in the proliferation anddifferentiation of keratinocytes and also functions as a potent T cell andneutrophil-chemotactic agent. Recent studies revealed that psoriasin exhibitsstrong antimicrobial activity and immune-regulatory effects in skin. Therelationship between psoriasin and skin diseases has gained more and moreattentions, but the mechanism of psoriasin in inflammatory skin diseasesremains unclear and further research is required into the effects of psoriasin ininflammation within the dermis.ObjectiveTo explore the expression of psoriasin in lichen planus and acute febrileneutrophilic dermatosis, and further understand its functional role ininflammatory skin disease, thus providing evidences for elucidating the activemechanism of psoriasin in the pathogenesis of skin diseases.MethodsFormalin-fixed, paraffin-embedded tissue blocks, which included lichenplanus and acute febrile neutrophilic dermatosis, were collected from theSecond Hospital of Jilin University dermatology clinic for the last16years(1996.06-2011.03). Immunohistochemical staining was applied to examine theexpression of psoriasin in lichen planus and acute febrile neutrophilicdermatosis.Results The expression of psoriasin was not observed in normal skin tissues. In30lichen planus tissue specimens, psoriasin was expressed with a positive rate of93.33%. In30acute febrile neutrophilic dermatosis specimens, psoriasin wasexpressed with a positive rate of86.67%. Compared with the control group, thepositive rates of the expression of psoriasin was significantly higher in lichenplanus and acute febrile neutrophilic dermatosis (P<0.01).Conclusions1) We firstly evaluated the expression of psoriasin in lichen planus andacute febrile neutrophilic dermatosis.2) The results showed that the expressionof psoriasin is upregulated in the dermis in lichen planus and acute febrileneutrophilic dermatosis.3) The upregulation of psoriasin may be involved inthe occurrence and development of lichen planus and acute febrile neutrophilicdermatosis.4) In the lesions of lichen planus, CD4+T cells infiltrated mainlythe dermis, and neutrophile granulocytes reassembled mainly in dermis in acutefebrile neutrophilic dermatosis, indicating that psoriasin not only is related withthe inflammation in the stratum corneum, but also could mediate thechemotaxis of inflammatory cells in the dermis.