Study On Correlation Between Helicobacter Pylori Infection And Recurrent Abdominal Pain

Helicobacter pylori infection is closely related with children’s recurrent abdominal pain.Recently datas from domestic and foreign show that one of life’s most main Hp infection age is in childhood.Hp infection can stimulate the body to produce specific antibodies,appear Hp-IgG,Hp-IgA,Hp-IgM in blood serum.Hp-IgG serological test to the diagnosis of Hp infection,the method simple,fast,high sensitivity.Recent studies have found that Hp infection is one of the main causes of recurrent abdominal pain in many children.Eradication of Hp can alleviate the clinical symptoms and improve gastric mucosal lesion.The data collected554cases of children with recurrent abdominal pain ELISA results,Hp-IgG antibody positive rate in children with recurrent abdominal pain is38.27%,the positive rate is unrelated to do with sex,but increases gradually with age,Hp-IgG antibody-positive rate of14years of age is46.67%,similar to adult,while the control group average Hp-IgG antibody positive rate is22.02%,the positive rate of two groups have significant differences.Enough to cause the majority of pediatricians and parents attention.It can be concluded that children’s recurrent abdominal pain is closely related with Hp infection.Hp strains Pathogenicity include vacuolar toxin gene(VacA gene), cytotoxic gene (CagA gene) and toxicity related gene protein.Hp strains are divided into type Ⅰ and type Ⅱ.type Ⅰ strains express VacA and CagA,type Ⅱ can not express.Hp-CagA positive strains may increase the risk of atrophic gastritis,which is associated with anti CagA antibody and glandular area reduction,polymorphonuclear cells and mononuclear cells increase,suggesting that type Ⅰ strains of Hp infection is closely related to atrophic gastritis, intestinal metaplasia,dysplasia and other precancerous lesions.The research studys on Hp-CagA antibody test of two groups that Hp-IgG antibody are positive,Abdominal pain group Hp-CagA antibody positive rate is84.43%, non-abdominal pain group is83.61%,the positive rate of the two groups have no significant differences.Chronic gastritis is a common disease of children,Hp infection is an important cause of chronic gastritis in children and an important factor to cause peptic ulcer disease.The data analysis shows that there are126cases of endoscopic gastric mucosa with varying degrees of changes in228apparent abdominal pain cases.Chronic superficial antral gastritis account for60.32%of the microscopic abnormalities,its Hp-IgG antibody positive rate is67.11%, gastric ulcer Hp-IgG antibody positive rate is50.00%,duodenal ulcer Hp-IgG antibody positive rate is55.00%.The degree of inflammatory lesions, Hp-IgG(+) are greater than those of Hp-IgG(-).gastric antrum is the most common in Children with chronic Superficial gastritis,involving the gastric body and angle in many cases.Lesions in the gastric antrum is the most heaviest.Its charact-eristic manifestation is multiple or diffuse protuberant erosion, umbilical-like erosion,diffuse granular change.Clinical manifestations associa-ted with inflammatory activity level,and further confirm that Hp is the cause of children with chronic Superficial gastritis,duodenal ulcer.Hp infection is closely related with the lifestyle and habits.in order to prevent gastrointestinal diseases, improve the cure rate and prevent the recurrence rate,we must actively control Hp infection.Hp is widely popular in the crowd.The majority of infected persons are without obvious clinical symptoms,therefore causing few attention.While with the understanding of the Hp-related diseases,people began to actively control the epidemic of Hp.Hp spread through patterns of fecal-oral,oral-oral,medical equipment,close contact and animal origin ect.The Hp infection rate in the developed and developing countries is different.In developing countries,more than70%to80%children are infected.While the infection rate is very low in developed countries,but the infection rate of age above40is50%to60%.In this study on the parents of68children with Hp infection.the results show that both parents’Hp infection positive rate in infected children’s homes is59.83%.In uninfected children’s home,both parents’Hp infection positive rate is11.11%.The difference is significant.Children have few outdoor activities, parents or closely contacted family members are the main source for the spread of Hp infection in children. With the increasing age of children,Hp infection rate increase significantly,suggesting that Hp may cross-infect in the family,existing family aggregation phenomenon.Hp infection in the body is generally difficult to remove and become chronically infected,causing chronic Superficial gastritis, Atrophic gastritis, peptic ulcer disease,existing abdominal pain,nausea,anorexia and other gastro-intestinal symptoms.This shows that Hp infection in children is closely related with recurrent abdominal pain.Prevention of Hp infection is crucial. Paying attention to oral hygiene to prevent the disease from the mouth is an important measure for prevention of Hp infection.Children should develop good lifestyle and dietary habits,avoid taking spicy,hot,cold,spicy food,prevent Helicobacter pylori infection in the family and the collective.If the child recur the upper abdomen or umbilical pain and other symptoms,parents should go to hospital earlier,in order to achieve early diagnosis,early treatment purposes.