The Correlation Between Inflammation-related Factors And TCM Syndromes In Fatty Liver Disease

Background:The investigation of the prevalence rate of TCM patterns in Hu Nan province clews that Dampness-Heat pattern is related to biochemical indexes which reflect the inflammatory injury of liver. On the basis of this, my clinical study was designed to reveal the correlation between inflammation of liver and TCM syndromes in Fatty Liver Disease(FLD) by inspecting inflammation-related factors of various TCM syndromes in FLD.Objective:This clinical study was designed to research the correlation between inflammation of liver and TCM syndromes in FLD by inspecting serologic indexes.Methods:Including221patients who met FLD-inclusive criteria and received treatments from November2009to April2012in the clinic of Gastroenterology, the clinic of health for senior cadres, and at the Department of Cardiology,the Department of Diabetes, the Department of Nephrology, the Department of Endocrinology,and the Department of Gastroenterology in China-Japan Friendship Hospital. They were divided into each syndrome type according their characteristics. Distribution of FLD patients was determined based on a well-established syndrome standard,And inspecting serologic indexes.The age and gender distribution for each syndrome pattern was investigated using descriptive statistical analysis. the relation of TCM syndrome with biochemical indexes was analyzed using Chi-square test,and The relation of TCM syndrome with Inflammation-related Factors was investigated with nonparametric test.Results:1). General information. The average age of221patients was50.37±13.838.The male to female ratio was1.83:1.2). TCM syndrome differentiation.221subjects were statistically differentiated as Dampness-Heat pattern, Heat pattern, Dampness pattern, Spleen-Deficiency pattern, and Blood-Stasis pattern.3).The relation of TCM syndrome with biochemical indexes.The abnormal rate of ALT,AST,GGT,TBIL was22.4%,8.5%,17.9%and5.8%.Comparison among groups of Abnormal rate of ALT was Blood-Stasis pattern>Heat pattern> Dampness-Heat pattern>Dampness pattern> Spleen-Deficiency pattern,P=0.03. Of79subjects,7subjects were abnormal in C reactive protein,taking up8.9%.4). The relation of TCM syndrome with Inflammation-related factors. Comparison among groups of Interleukin1β Interleukin6、Tumor necrosis factor-a were Heat pattern> Spleen-Deficiency pattern> Dampness pattern> Blood-Stasis pattern>Dampness-Heat pattern, Blood-Stasis pattern> Spleen-Deficiency pattern >Dampness-Heat pattern>Dampness pattern> Heat pattern, Dampness-Heat pattern>Blood-Stasis pattern> Dampness pattern> Heat pattern> Spleen-Deficiency pattern, P>0.05. Comparison among groups of Interleukin4was Blood-Stasis pattern> Spleen-Deficiency pattern> Heat pattern> Dampness-Heat pattern> Dampness pattern,and P<0.01. Comparison among groups of Interleukin10、Transforming growth factor-β1were Heat pattern> Spleen-Deficiency pattern> Dampness pattern>Dampness-Heat pattern> Blood-Stasis pattern, Heat pattern> Spleen-Deficiency pattern> Dampness pattern> Blood-Stasis pattern> Dampness-Heat pattern, P>0.05.Conclusion:1). Dampness-Heat pattern and Heat pattern were the main TCM syndrome patterns in This group of patients with FLD.2).Heat pattern and Dampness-Heat pattern with more hepatic dysfunction have lower level of anti-inflammatory cytokine which means pattern mainly with dampness and heat have stronger inflammatory reaction.