Investigate The Histogenesis Of Intracardiac Leiomyoma By Immunohistochemical Technique

Objective:Explore the histogenesis of intracardiac leiomyomatosis (ICL) to provide some basis for the study of ICL pathogenesis.Methods:A case of tumor specimens of patients who accepted successful one-stage operation treatment of intracardiac leiomyomatosis was studied with immunohistochemical markers (CD10, CD34, ER, PR, Desmin and SMA), and was investigated the histological origin by comparing the results of immunohistochemical markers.Results:The tumor of about37cm, diameter3cm to5cm, smooth and tough, originated from right common iliac vein, extended into the inferior vena cava and reached right atrium. The tumor was composed of mature fusiform smooth muscle cells and blood vessels. On the surface of the tumor, there was a layer of endothelium. Immunohistochemically, the tumor cells showed CD10(-),CD34(-), ER(++), PR(+++), Desmin(++), and SMA(+++); Endothelial cells on the surface showed CD10(-), CD34(-), ER (-), PR (-), Desmin (-) and SMA (-); Vascular endothelial cells in the tumor showed CD10(-), ER (-), PR (-), Desmin (-) SMA (-) and CD34(+++); Vascular wall cells in the tumor showed CD10(-), CD34(-),ER (-),PR (-), Desmin (-), and SMA (+++)Conclusions:The histogenesis of intracardiac leiomyomatosis of this case was uterine leiomyoma. The uterine leiomyoma invaded the neighboring vasculature, grew along the refluxing direction of the venous channels, beyond the uterus, and along uterine vein or ovarian vein, extended into the inferior vena cava, reached the right atrium and finally resulted in intracardiac leiomyomatosis.