Relationship Between Carotid Atherosclerosis Of Phlegm-Dampness Syndrome With Essential Hypertension And Left Ventricular Hypertrophy

Objective: To study the relationship between carotid atherosclerosisof Phlegm-Dampness Syndrome with essential hypertension(EH) and leftventricular hypertrophy (LVH). Methods: Between March2011and October2011,121AS with EH patients(56Phlegm-Dampness Syndrome patients and75Non-Phlegm-Dampness Syndrome patients)、40AS patients with non-hypertension diseases and25patients with non-AS(control group) wereenrolled。The diagnostic crite-rion of thickened carotid intima was setas1.0mm≤intima-media thickness（IMT）＜1.2mm. Carotid atherosclerosiswas divided into three levels: normal intima, thickened intima,and plaqueformation. According to the color Doppler ultrasonography echocharacteristics，carotid plaque was divided into the hard plaque、the softplaque and the mixed plaque.We measure the left ventricularend-diastolic dimension（LVEd）、inter ventricular septumthickness（IVS）、left ventricular posterior wall thickness（LVPW）、ejection fraction（EF）、left ventricular fractional shortening（LVFS）using Dopplerechocardiography and count the left ventricular mass index（LVMI）。Thecolor Doppler ultrasonography data of all patients were analyzed and theseverity was compared.Results: The LVES、LAD、AOD、LVPW、IVS in AS withEH group was higher than control group（P<0.001），the SV in AS with EHgroup was higher than that in AS with non-hypertension group（P<0.05），which illustrate that AS with EH group has noticeabler trend than AS withnon-hypertension group；The LVED、LVES、LAD、AOD、IVS、LVPW、E/A、SV、LVMI in Phlegm-Dampness syndrome with EH in AS group was higher thancontrol group（P<0.001），the IVS、LVPW in Phlegm-Dampness syndrome with EH in AS group was higher than Non-Phlegm-Dampness Syndrome with EH inAS group（P<0.05），which illustrate that the severity of the changes ofcardiac structural in Phlegm-Dampness syndrome with EH group was higherthan that Non-Phlegm-Dampness Syndrome with EH group； There wassignificant difference in LVED、LAD、IVS、LVPW、E/A、SV with the thickenedintima group、the hard plaque group、the soft plaque group and the mixedplaque group in EH with AS（P<0.05），according to difference in theconstitution of carotid plaque.which illustrate that there wassignificant difference in the constitution of cardiac structural andfunctional with varying degrees in AS.There was no difference in theconstitution of carotid plaque between AS with EH group and AS with non-hypertension group.and there was no difference in the constitution ofcarotid plaque between Phlegm-Dampness syndrome with EH group andNon-Phlegm-Dampness Syndrome with EH group.Conclusions: EH patients haveinvarying degree on the carotid atherosclerosis and left ventricularhypertrophy.specially patients of Phlegm-Dampness Syndrome with EH,thecarotid atherosclerosis is closely related to left ventricularhypertrophy than Non-Phlegm-Dampness Syndrome group with EH.