| Objective: To study the applied value of duplex ultrasound in foundamentalresearch and clinical reseach of preventing and curing Carotid Atheromatosisby means of Chinese medicine . Methods: In the part of experimental study, 47 Japan purebred flap-earedwhite rabbits were divided randomly into three groups: normal control group,model group and fake operation group. Carotid in model group is burnt byelectricity with the appearance of forming thrombus,and this group is fed byusing the high fat fodder for 8 weeks.After the RS models was built by PTA,model group was divided randomly again into four groups based on the evaluationresult of Carotid Atheromatosis degree which was measured by ultrasound andconsulted blood fat and body weight of animals. They are traditional Chinesedrug A group(Capsule of Xue Fu Zhu Yu), traditional Chinese drug B group(Prescription of Detoxifcation, Promoting Blood Circulation and ReinforcingQi), western medicine group(Pravastatin and Solution of Crystar) and modelgroup. Inside diameter, membrane thick, peak speed of Systole, pulse indexand resistant index of carotid was measured at the start, the 8 week end andthe 12 week end. Being or not of atherosclerosis plaque was observed. Comparedwith measured value of ultrasound and measured value of pathology, diagnosticvalue of ultrasound in rabbit carotid atherosclerosis plaque was evaluated .The narrow states of blood vessel evaluated by ultrasound and pathologicalresult were compared and analyzed. The experiment result of traditionalChinese medicine was analyzed. In the part of clinical study, carotid and heartchecks were synchronously carried out for 92 essential hypertension patients.Being or not of atherosclerosis plaque was observed, Inside diameter,intimal-medial thickness , peak speed of Systole, pulse index and resistantindex of carotid , mass index of left ventricle, EF ejection numerical valueand E/A specific value of left ventricle was measured. Zang-fu syndromedifferentiation and Qi-Blood-Yin-Yang syndrome differentiation wereundertaken to the patients according to deficiency and blood stasis syndromesstandard which was revised by Chinese combination of TCM and western medicineacademy in 1986. Results: In the part of experimental study, (1)The sensitivity ofultrasound in rabbit carotid atherosclerosis plaque detection is 88.89%, thespecific is 85.71%, the veracity is 83.33%. There are lipid, collagen, calciumsalts and hemorrhage in the atherosclerosis plaque. (2) The method thisexperiment has taken to evaluate straitness of blood vessel has high level- 4 - 双功能超声技术在中医药防治颈动脉粥样硬化斑块中的实验'临床研究positive correlation with pathology result, R=0.702,P<0.01. It is simplemethod for easy operation and worthwhile popularize. In the part of clinicalstudy, (3) The result clues on clinical doctor in the working of preventingand curing hypertensive disease with method of combination of TCM and westernmedicine: Although blood pressure level is not high, high risk patients hidethere. Patiens of semplice systolic hypertension have potentially high risk.So high blood pressure level don't equal risk level. (4) Maybe there is ruleas follow in target organ damage of hypertensive patients in our country: Thetime carotid atheromatous plaque occuring is earlier than the hypertrophy ofleft ventricle and incidence of the foremer is higher. Carotid atheromatousof essential hypertension patients have characteristics as follow: Carotidatheromatous plaques occur easily at posterior wall of common carotid arterycroth. Plaques are mainly hard ones. The intimal-medial thickness of carotidwhere atheromatous plaque occur is thicker than that where atheromatous plaquedo not occur. The essential hypertension patients with hypertrophy of leftventricle have more obvious cardiac function damage than other hypertensionpatients. (5) The target organ damage of hypertensive have a certain extentrelation to disease type... |
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