The Comparative Study Of Cilostazol And Aspirin In Neuroprotection And Bleeding Side Effect

Objective：1.Establishing the mouse model of middle cerebral artery occlusion2.Observing the impact of cilostazol on cerebral hemorrhage3.Observing the impact of cilostazol on the blood-brain barrier permeability4.Observing the neuroprotective effect of cilostazolMethods：130mice were divided into sham group, control group, cilostazol group(10mg/kg), aspirin group(30mg/kg). Surgery of Middle cerebral artery occlusionwith3hours occullsion and21hours reperfusion were proformed on the mice of thelast three groups.The brain water content,infarct volume, neurological deficit scores,Evans blue content and volume of cerebral hemorrhage volume were measured at24hours after the surgery.Results： The infarct size, brain water content, the hemorrhage volume, Evans Bluecontent of the sham group were lower than the other three groups (P <0.05). Amongthe other three groups, the infarct volume, water content,Evans blue content andhemorrhage volume were different in population(P<0.05). cilostazol had minimumwater content and infarct size, and had a smaller infarct size compared with thecontrol group (P <0.05).The infarct size of the aspirin group was smaller than thecontrol group,but the hemorrhage volume was larger than the other two(P<0.05).Theneurological deficit scores of all three groups were reduced(P<0.05),but the differencewas not significant among them(P>0.05).Conclusion： Cilostazol and aspirin can protect the brain by reducing the infarctsize,this may be achieved by improving cerebral blood supply. However, aspirinincreased the risk of cerebral hemorrhage, which could be the reason of lager watercontent of the aspirin group. Neurological deficit score of the three groups were allreduced, but there was no significant difference among them, which may be caused byshorter interval between the two grading time point.And the neurological improvement had not fully displayed. In conclusion cilostazol can reduce infarctvolume and has no significant bleeding side effect in acute ischemic stroke; Aspirinreduces infarct size while increasing cerebral edema and bleeding risks.