Related Factors Of The Classification And Prognosis Of Inflammatory Demyelinating Polyradiculoneuropathy

Objective Investigate the characteristics of the clinical manifestationsand auxiliary examination of inflammatory demyelinating polyradiculoneuropathy，analyse the characteristics of the sub-types and the prognostic factors. Method Theretrospective study in classification and prognostic factors of patients withinflammatory demyelinating polyradiculoneuropathy who hospitalized in theDepartment of Neurology of First Affiliated Hospital of Fujian Medical Universityfrom March2006to September2011. Result The differences of cerebrospinal fluidprotein content (P=0.027), prodromic infection (P=0.000), muscle atrophy (P=0.000) and cranial nerve symptoms (P=0.009) were statistically significant betweentwo groups of different peak time(AIDP group and CIDP group). The difference of themuscle strength score in the peak tim（eP=0.000）was statistically significant betweentwo groups of different severity (mild group and non-mild group).The differences ofthe muscle strength score in the peak time（P=0.000）and the Hughes score inadmission（P=0.000）were statistically significant between two groups of differentprognosis(good prognosis group and poor prognosis group). The differences oftreatments were not statistically significant between two groups of different prognosisneither in AIDP group nor in CIDP group.In AIDP group,the differences of theimprovement of Hughes scores from admission to discharged among four treatmentswere statistically significant（P=0.023）;. the differences of the improvement ofHughes scores from admission to discharged was statistically significant not onlybetween glucocorticoid and neurotrophy but also between glucocorticoid+gammaglobulin and neurotrophic（P=0.008、P=0.010）; the differences of theimprovement of Hughes scores from admission to discharged was not statisticallysignificant between glucocorticoid and glucocorticoid+gammaglobulin,glucocorticoid and gammaglobulin, glucocorticoid+gammaglobulin andgammaglobulin, gammaglobulin and neurotrophy（P=0.866，P=0.088，P=0.104，P=0.384）. In CIDP group,the differences of the improvement of Hughes scores from admission to discharged among four treatments were not statistically significant（P=0.620）. Conclusion The level of cerebrospinal fluid protein content,theprodromic infection, the cranial nerve symptoms and the muscle atrophy are good fordistinguishing AIDP form CIDP.The muscle strength score in peak time is related todifferent severity that mild cases have high muscle strength score.The muscle strengthscore in peak time and the Hughes score in admission would predict the prognosis. InAIDP group, those were treated with glucocorticoid or glucocorticoid andgammaglobulin is more effective than those treated alone with neurotrophic in theimprovement of movement disorders,which was not found in CIDP group.