Expression And Significance Of ROCK-2and CD44v9in Breast Cancer Tissue

Objective：This experiment is to detect ROCK-2protein and CD44v9protein levelsbetween breast cancer tissues and normal tissues，and their clinicl significances andtheir relationships.Methods：We have collected54cases of breast cancer tissues and20normal tissuesof paraffin specimens from Linyi Chinese medicine hospital,then detected theexpression of ROCK-2and CD44v9proteins by Immunohistochemical method.Results：1. The expression of ROCK-2protein in normal breast tissue has not beenseen.We found the positive expression in44of the54Breast cancer (81.48%).Therecords of a transfer is89.74%in39cases,and60.00%in15cases.2. The positiveexpression of CD44v9protein has been found in40of the54(74.07%) breast cancer.And5of the20normal breast tissue is(25.00%).Their positive expression hassignificantly statistical significance.(P＜0.05)3. ROCK-2protein and CD44v9protein in breast cancer tissue of the expression level, with increased cancer stage andheighten4. ROCK-2protein expression was correlated with CD44v9proteinexpression in the Breast cancer (r=-0.459, P＜0.05).Conclusions：1. The expression of ROCK-2protein in normal breast tissue has notbeen seen, however it has a high leavl in Breast cancer tissue. This show that it maybe promote the development of Breast cancer and may be provide a new way to treatBreast cancer by target molecule:to destroy or disturbance Rho/ROCK-2.2.The highespression was correlated with CD44v9protein expression in Breast cancer and tisleval of expression in cancer is obviously higher than normal tissues. It show thatCD44v9has a importment significance in transfer and prognosis as a metastasisrelative gene.3. ROCK-2protein and CD44v9protein may have a synergistic action inthe invarion and metastasis in Breast cancer. But the real relationship of them intransfer need more study.