The Effect Of Different Dosages Of Ulinastatin On Serum S-100B Protein,NES, Oxygen Metabolism And ICP In Patients With Severe Traumatic Brain Injury

Objeetive:Find the rules of dynamic changes of biochemical markers,oxygenmetabolism and ICP in patients with severe traumatic brain injury，and explore thetherapeutic effeet and mechanism of ulinastatin to give the reference of diagnosis andtreatment.Methods:Choose27Patients，Whose Pre-hospital time was in24hours，diagnosedsevere traumatic brain injury（GCS3to8） to fulfill the research.The date wasrestrieted from Aus.2010to Aus.2011.These patients were randomly divided into theregroups by different dosages of ulinastatin.The patients in low dosage group（n=8） whowere used ulinastatin10thousand units per6hours from the first day in hospital，continuing5days.The high dosage group（n=7） was injected ulinastatin40thousandunits and The control group（n=12） was only under the basic treatment. Blood sampleswere taken via retrograded jugular blub cannula. To conpare the serum S-100Bprotein,NES, oxygen saturation of jugular blood （SjO₂）, arteriovenous difference oflactic acid（VAlac）, regional cerebral oxygen saturation （rScO₂） and intracranialpressure（ICP）.Results:Compared to the control group, serum S-100B protein,NES of highdosage group were decreased greatly in the3^th,5^thdays after sTBI （p＜0.05）, SjO₂ofhigh dosage group were decreased greatly in the3^thdays after sTBI （p＜0.05）, rScO₂of high dosage group were elevated greatly in the2^thto5^thdays after sTBI （p＜0.05）,ICP of high dosage group were elevated greatly in the3^thto5^thdays after sTBI （p＜0.05）,there wasn’t obvious difference among three groups in VAlac.Conclusion:High dosage ulinastatin will decrease serum S-100B protein,NES ofpatients with sTBI, improve oxygen metabolism and alleviate brain edemasinificantly.