Relevance Analysis Of Age-related Body Fat Distribution And Metabolic Syndrome

Objective: To investigate the regulation between body fat distribution and Each partof the fat quality ratio caused by aging, and the relationship between age-related bodyfat distribution and metabolic syndrome.Methods: First,2316people (1131male,1185female) are measured their fat andmuscle mass by using dual energy x-ray absorptiometry(DEXA), and calculatevarious parts of fat mass/total body fat mass ratio (arm, leg, limbs, trunk fat mass/totalbody fat mass are respectively marked AF/TF、LF/TF、LiF/TF、TrF/TF), various partsof the fat mass ratio (trunk fat mass/arm，leg，limbs fat mass are respectively markedTrF/AF、TrF/LF、TrF/LiF). According to gender and obesity (BMI≥25.0Kg/m~2), theywere individed into male obesity group, male non-obesity group, female obesitygroup and female non-obesity group,which were individed into five groups in eachlevel. Then, we compare the relevance ratio of hypertension, hyperglycemia,dyslipidemia between each different age level by chi-square test. The relationshipbetween body fat distribution and metabolic abnormalities was assessed by usingPearson correlation, and to compare the influence they have on metabolic syndromeby Logistic regression analysis.Results:(1) With age increasing, AF/TF: there is no differences (P>0.05); LF/TF andLiF/TF: male non-obesity groups all decrease and then have rebounded (P<0.01),male obesity groups decrease gradually, female obesity and non-obesity groups bothdecrease with aging (P<0.01); TrF/TF, TrF/LF and TrF/LiF: male non-obesity groupsincrease first and then fell (P<0.01). Male obesity groups, female obesity andnon-obesity groups all show an increasing trend (P<0.01); TrF/AF: There is anincreasing trend in male obesity groups, female obesity and non-obesity groups(P<0.01).(2) Relevance ratio of hypertension:There show an increase with the risingage in all male and female groups; Relevance ratio of hyperglycemia: femalenon-obesity groups, male obesity and non-obesity groups lift with age increasing(P<0.01), while female obesity groups show an rising, the difference was notstatistically significant (P>0.05); Relevance ratio of high TG: With aging,there is no differences between male obesity and non-obesity groups (P>0.05), while femaleobesity and non-obesity groups rising (P<0.01); Relevance ratio of low HDL-C: Itshows no differences between male non-obesity, male obesity groups and femaleobesity groups with age increasing (all P>0.05), but female non-obesity groupsshowed an rising trend (P<0.05).(3) There were significantly positive correlationsbetween FBG, SBP, DBP, TG and age，TrF/TF, TrF/AF. However, there were nocorrelation between these metabolic indices and TrF/TF, TrF/AF in Male obesitygroup. FBG, SBP, DBP, and TG with LF/TF was a negative correlation, which wereno significant correlation with AF/TF. There were positive correlations betweenHDL-C and LF/TF, and negative correlation between HDL-C and TrF/TF，TrF/LF.(4)Multiple regression analysis: It showed that high blood pressure was dependentvariables, age and TrF/LF in male entered the equation,and age，TrF/TF in female；when we use glucose metabolic abnormalities as dependent variables,age and LF/TFenter the equation in male non-obesity groups，then age and TrF/TF in male obesitygroups and both of female groups；Finally，we use lipid metabolic disorder asdependent variables, TrF/LF、TrF/AF were in male non-obesity groups，LF/TF was inmale obesity groups, while TrF/TF was in female both groups.Conclusion: Increasing in trunk fat and decresing in lower limb fat are importantfactor which caused metabolic syndrome with aging，and both of them promote thisprocess.Young obese patients should attach importance to administration of bloodlipid earlier.