Study On BuShenYiJing Tablet

Oligospermia is the number of sperm in semen is lower than the normal healthy fertile men in a male disease. In recent years the quality of human sperm with the environment, toxic pollution, estrogens and other factors decreased. Now that the number of sperm per milliliter less than 20 million sperm. However, often accompanied by clinical low sperm motility, forward movement is poor and the high rate of change in sperm abnormality, this time called Asthenospermia less and less sperm is a relatively common disease of male infertility.Compound BuShenYiJing Tablet’s creation is based on the WuZiYanZong pill by a Well-known traditional Chinese medicine doctor in andrology. Compound BuShenYiJing Tablet has With a nourishing liver and kidney, fill fine spermatogenesis, the effect of spleen Qi and blood. Indications Kidney essence deficiency, blood deficiency caused by oligospermia. Compound BuShenYiJing is decoction,which widely used in clinical practice. In order to meet the needs and requirements of patients, according to requirements of modern Chinese medicine preparation, In order to improve the traditional BuShenYiJing decoction to modern Chinese medicine,several research were carried out by pharmacodynamics and toxicological methods,as well as quality analysis and modern extraction and purification technology.In the extraction and purification technology study,we used the transferate of Osthol and extracting ratio as evaluating indexes and investigated the optimum ethanol extraction process by the orthogonal test method,we used the transferate of Osthol and Stilbene Glucoside, extracting ratio as evaluating indexes and optimized the optimum water extraction and alcohol precipitation process by the orthogonal test and the single factor methods. the preparation study, we ensured the stability of capsule, and aiso studied the optimum preparation process.We established the quality standard of Compound BuShenYiJing Tablet incuding qualitative identification and quantitative determination. Lycii Fructus,Astragali Radix,Fibraureae Caulis,Angelicae Sinensis Radix, Achyranthis Bidentatae Radix, Cuscutae Semen,Paeoniae Radix Rubra were qualitatively analyzed by TLC, Osthol and Stilbene Glucoside were quantitatively measured by HPLC.Other inspections such as collapse,heavy metals,arsenic were also detected.This method is accurate and highly reproducible.It can be used for the quality control of Compound BuShenYiJing Tablet.Compound BuShenYiJing Tablet through to kidney positive diseases of general debility model animal’s influence experiment; To castrates the big mouse penis erection and the vice-reproductive organ and the androgen level influence experiment; To big mouse copulation behavior influence experiment as well as to mouse oligospermia model animal’s testicle and epididymis influence experiment. Results showed that the tablet has Kidney yang,and the role of germ.Through the study of CompoundBuShenYiJing Tablet,the preparation process was reasonable and practicable,the quality standard was accurate and highly reproducible,Pharmacological effect was obvious. BuShenYiJing Tablet meet the requirements of modern medicine.