Comparison Of Sevoflurane Anesthesia Between Puppies And Adult Dogs

Sevoflurane is a widespread new inhalation anesthetic in daily case of small animal veterinary in the devoloped countries. It has low solubilities in blood, less cardiovascular effect and dose depended respiratory inhibition. The metabolic rate of sevoflurane in dog is5%. Sevoflurane is not only commonly used for induction and anesthesia maintenance in adult dogs and cats, but also in pups and kittens. Sevoflurane are commonly used for anesthesia in adults and pediatrics in the veterinary clinics aboad but are rarely seen in China.12two-month-old puppies and121～1.5years old dogs were chosen in this experiment. The effects of two deferent types of procedure based on sevoflurane in aldut dogs and puppies during anesthesia and recovery period were studied.Experiment I:Effects of Sevoflurane Anesthesia on Cardiopulmonary Function of Adult DogsObjective:The aim of the present experiment was to study the cardiopulmonary effects of sevoflurane anesthesia on aldut dogs. Procedure:Two tentative anaesthetic protocol were used to anaesthetise12aldut dogs for study. Dogs were randomly allocated to two groups (group A and group B),6in each group. All the dogs were premedicated with Shumianning. After, group A was induced via mask, with8%sevoflurane, group B was induced with propofol. Both group were maintained with a vaporizer seting of3%sevoflurane and an oxygen flow rate at2L·min-1in the first5minuts, then with a vaporizer seting of2.5%sevoflurane and an oxygen flow rate at30mL·kg-1·min-1in the next30minuts. RT, HR, NIBP, SPO2, RR, PetCO2, MV, VT were measured during anesthesia. Results:There’s no signeficant difference on all the cardiopulmonary values between groups. RR measured in both group were significantly lower than baseline. RT measured in group B was also significantly lower than baseline. No significant differences were found in other parameters. Conclusions:Both anesthesia procedures have less inhibition on the cardiovascular system and more effects on the respiretory systems of dogs. Using propofol for induction may cause lower temperature. Shumianning is beneficial for the stabilities of the cardiopulmonary system during induction and anesthesia maintenance in adlut dogs.Experiment II:Effects of Sevoflurane Anesthesia on Cardiopulmonary Function of PuppiesObjective:The aim of the present experiment was to study the cardiopulmonary effects of sevoflurane anesthesia on pups. Procedure:The puppies were randomly allocated to two groups (group A’and group B’),6pups in each group. All the pups were premedicated with Shumianning. The induction methods in group A’and B’ were as the same as group A and group B in experiment I. Both group were maintained with a vaporizer seting of4%sevoflurane and an oxygen flow rate at2L· min-1in the first5minuts, then with a vaporizer seting of2.5%sevoflurane and an oxygen flow rate at100mL·kg-1·min-1in the next30minuts. RT, HR, IBP, SPO2, RR, PetCO2, MV, VT and blood gas values were measured during anesthesia. Results: There’s no signeficant difference on all the cardiopulmonary values between groups. In both group, compare to the baseline, PetCO2parameters were significantly higher, RT parameters were significantly lower and IBP parameters also changed significantly. In each group, pH parameters were out of the lower bound of the nomal range slighty and PaCO2parameters were a bit higher than nomal. No significant difference were found in other parameters. Conclusions:Both anesthesia procedures have less inhibition on the cardiovascular and respiretory system of dogs. Mild respiratory acidosis may occur during anesthesia in puppies.Experiment III:Comparison of the quality of anesthesia and time required for induction and recovery on puppies and aldut dogsObjective:The aim of the present study was to compare the quality of anesthesia and recovery, drug does and time required for induction and recovery among all the groups of aldut dogs and puppies. Procedure:The anesthesia methods were told previously. The premedicated dose of Shumianning was recorded in all groups. During Induction period, the time from the start of mask induction to negative tail-clamp response, to loss of palpebral response, to intubation in group A and A’and propofol dose that required for induction in group B and B’were recorded. During recovery period, the time from discontinuance of the volatile agent to appearance of palpebral reflex(TⅠ), to extubation(TⅡ), to sternal recubancy(TⅢ), to standing(TⅣ) and to walking(TⅤ) were record. The quality of sedation, induction, intubation, anesthesia and analgesia during anesthesia maintenance and recovery period were assessed in all the groups. RT、RR、HR、PetCO2values measured at10,25,40,55minutes after zeroing of the vaporizer were recorded. Results:The requaired dose for Shumianning in aldut dogs were0.04～0.05mL·min-1and in puppies were0.03mL·min-1. There had no significant defference in induction time between group A (232.5±17.92s)and A’(257.83±40.89s), but in propofol dose between group B(4.18±1.53mg· kg"’)and B’(2.98±0.47mg·kg-1). The analgesia quality was better in adult dogs than in puppies during anesthesia maintenance. There were no significant differences in T1, T n but in Tm, Tiv, Tv in puppies compared with adult dogs. Conclusions:The sedative ability of sevoflurane is quite well in puppies, but analgesic ability is trivial. The dose of propofol and shumianning should be less in puppies than in adult dogs but the time required for induction are all the same. Puppies need more time and nursing after anesthesia.