Synthesis Of Moxifloxacin Hydrochloride By Limin Wen

Moxifloxacin, one of newly fluoroquinolones drugs, bears broad-spectrum antiseptic activity. It holds antigram’s negative aerobic high activity, and has strong antiseptic activity for anaerobic bacteria, mycoplasma, Chlamydia, legionnella and also. Especially, it has obviously effect in counterwork of goldenchaincoccus, enterococcus, colibacillus and other strains, which have drug tolerance to antibiotics. Its activity is equal to or excelled to other drugs, which now we use. Also it has upstanding Pharmacokinetics character, the lower drug resistence, and the higher security. As a new antiseptic drug, it has very extensive prospect, wild potential in the market.Based on the analyse of the methods in documentary synthesis of Moxifloxacin Hydrochloride, a synthesis method of Moxifloxacin Hydrochloride is proposed through bench-scale testing combined with the practical situation of the industry. In this project, a process which is of high purity, high profit and low cost is selected. And the Methoxy cyclization ester and the (s, s)-2,8-Two azabicyclo [4.3.0] Nonane are chosen as the law material. It is confimed by the chemical structure that the target product is proved to be moxi. The yield of optimized process product is between65.2%and65.7%.All products were characterized by modern analytical methods including UV, IR, NMR and MS, and their structures are assured.