Studies On Synthetic Route And Related Impurities Analysis Method For Moxifloxacin Hydrochloride

Moxifloxacin is the fourth generation synthetic antibacterial drugs of 8-methoxy fluroquinoloncs.It has wide antibacterial spectrum,high antimicrobial activity,high safety and low resistance,and etc.Moxifloxacin has been widely used in clinical application,mainly used for respiratory diseases,gastrointestinal diseases.In recent years,incidence of respiratory diseases increased year by year because of the impact of reduced environmental pollution,low air quality,and the aging population factors.The utilization rate of moxifloxacin is also on the rise in the drug market.Therefore,the new synthesis technology and relative detection method research of moxifloxacin hydrochloride has an important theoretical and practical research value.The main research contents of this paper include:Using(1-cyclopropyl-6,7-fluoro-8-methoxy-4-oxoquinoline-1,4-dihydro-3-carboxylic acid)and((S,S)-2,8-azabicyclo [4,3,0] nonane)as the starting materials,boron complexes of three fluorine acetic acid with strong electron withdrawing ability as chelating agent,the new synthesis process was optimized with higher product quality.Using bonded porous silica microspheres(referred to phenyl column)as the stationary phase and gradient elution mode,the quantitative determination of moxifloxacin hydrochloride and related substances were studied by HPLC.The results show that this method can detect the content of moxifloxacin hydrochloride and related the impurities(including intermediates and process impurities)rapidly,accurately and simplely.It has an important significance for quality control of moxifloxacin hydrochloride.This research laid the foundation for further industrialization of moxifloxacin hydrochloride.