Synthesis And Characterization Of New Diazaphospholes Compounds And Nickel And Cobalt Metal Complexes

The 1H-1,2,4-diazaphosphole derivatives have presentedantitumor activity and might be precursor for drug design . In thisthesis, we designed and synthesized four new symmetrical N-Pheterocyclic compounds, which of the raw materials for furtherstudy on the design of new pharmaceutical intermediates.According to the charge distribution analysis of the deprotonateddiazaphosphospholes, they have shown to be excellent ligands forthe formation of metal complexes in different coordination modes.Of which a large part of complexes is widely used in magneticmaterials. In the article we also designed and synthesized two kindsof pyridine-bridging diazaphospholes metal complexes. Specificwork is as follows:1. In this thesis, we synthesized four novel symmetricaldiazaphospholes compounds with the substituents are methy ,1-naphthyl, 2-furyl, 2-thiophyl in three-step reaction, which with theamide or chloride as raw materials. And they are characterized by NMR, Elemental Analysis and XRD .In addition, depth discussions ofthese compounds in the structure nature are shown in the work.2. In the assay, we also synthesized the pyridine-bridgeddiazaphospholes–2,6-bis（3,5-dihydro-diazaphospholes）pyridine withthe new method. It is also characterized by the NMR.3.In this article , two kinds of magenetic compounds weresynthesized by the 2,6-bis（3,5-dihydro-diazaphospholes）Pyridineand Co（ClO₄）-6H₂O（Ni（ClO₄）-6H₂O）. And the compounds werecharacterized by NMR, elemental analysis, XRD, magnetic andother means to the structure.The present work is not only providing the raw materials forfurther study of synthesis of metal complexes of free radicalperformance, but also guiding the direction for future magneticresearch by the magnetic characterization of the two metalcomplexes.