| Objective: To observation the infection of Helicobacter pylori (H.pylori)on long-term and low-dose aspirin application to patients, and the relationshipbetween Helicobacter pylori infection and age in long-term use of thelow-dose aspirin in patients; Helicobacter pylori positive livestock rate ofIschemic cardiovascular and cerebrovascular disease,and provide the basisfor the prevention and treatment of cardiovascular and cerebrovasculardiseases.Method:1Case selection: Digest the age of Gastroenterology,Cardiology, Neurologydepartment visits in patients over the age of45in September2010to February2012from the Third Hospital of Hebei Medical University.Detection ofH.pylori infection2experimental reagents and equipment requiredOlympus production of electronic gastroscope (GIF-H260, GIF-XQ260,GIF-XQ240, GIF-XQ230), disposable biopsy forceps, Ningbo Uni-BioScience Co., Ltd. produced by H.pylori rapid diagnostic kits, Shenzhen andsea Dulwich biotechnology Co., Ltd. production of14C-urea capsule, the set ofcylinders of CO2and scintillation liquid, the H-of UBT-01liquid scintillationHelicobacter pylori (H.pylori) tester, centrifuge, Beijing Hong Mei Tianhongbiotechnology Co., Ltd of H.pylori urease antibody detection kit (colloidalgold method).3methods3.1Grouping and detection methods:1142patients Conform to the inclusioncriteria, People were divided into the aspirin group and control groupaccording to the long-term oral administration of aspirin,346cases takeenteric-coated tablets with75mg or100mg daily,and the time for medication for more than1year,796cases of the control group not taking aspirin andother non-steroidal anti-inflammatory drugs,compared to the group of H.pyloriinfection;346cases were selected with long-term oral administration ofaspirin, divided into four groups according to age, respectively,83cases are45～54years old;125cases are55～64years old;87cases are65～74yearsold;51cases exceed75years old,and compared Helicobacter pylori infectionof each group; select a long-term oral administration of aspirin as ischemicheartsecondary prevention of cerebrovascular disease patients, divided into190cases with cardiovascular disease,91cases with cerebral vascular diseasegroup were compared between H. pylori infection.3.2Diagnostic criteria of H.pylori infection: Either a positive can bediagnosed in the following checks for H. pylori infection,14C-urea breath test,gastric mucosa rapid urease test (Hp-RUT), H.pylori urease antibody detection(colloidal gold method).3.3Statistical methods: SPSS17.0software for statistical analysis, count datawere compared with the χ2test, multiple samples mean were compared withanalysis of variance, significant difference Prompted by P <0.05. Multiplesamples are array of pairwise comparisons, P <0.0083(0.05/6) was consideredstatistically significant.Results:H.pylori-positive51.16%in aspirin group,and44.10%in control group,there's statistically significant difference(χ2=4.837,P=0.028).H.pylori infectionrate in patients taking Long-term oral aspirin in every age stages was:45～54years old for42.16%,55～64years old for58.40%,65～74years old for55.17%,41.18%in exceed75years. There's no statistically significantCompared between each group. H.pylori-positive was50.35%in coronaryheart disease group,51.65%in cerebrovascular disease group, There was nosignificant difference between the coronary heart disease group and theischemic cerebrovascular disease group (χ2=3.518, P=0.058).Conclusion:1H.pylori infection was higher in long-term taking aspirin than the control group, so taking aspirin in long-term should be noted that the detection ofH. pylori to prevent and reduce gastrointestinal injury.2H.pylori infection rate wasn't associated with the patient age of takingaspirin in long-term.The result is inconsistent with the literature.Furtherstudies need to be done to solve the problem.3There's no significant different in Helicobacter pyloripositive rate ofpatients taking aspirin in long-term with coronary heart diseaseor ischemic cerebrovascular disease. |
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