The Evaluation Of Microembolic Signals To Antithrombotic Agents

Objective To investigate the difference of the number of MES between antithrombotic agents, and the incidence of MES between transient ischemic attack (TIA) and cerebral infarction (CI). And to study the affect of the risk factors as so well as hs-CRP to MES in patients with cerebral ischemia.Methods 60 patients were enrolled, on whom MES monitoring was performed for 60 minutes. For MES positive patients, they were treated with aspirin+clopidogrel or aspirin +clopidogrel+atorvastatin. MES were monitored with TCD at different time after treatment. Effect of aspirin+clopidogrel or aspirin+clopidogrel+atorvastatin on MES were observed.Results Among 60 patients, MES were detected in 13 patients(21.7%). Seven patients were administered with aspirin+clopidogrel,the others with aspirin+clopidogrel+ atorvastatin.Monitoring of MES was done on day 2 and 7. Both the treatments can reduce MES. The number of MES of dual antiplatlet group was more than that of dual antiplatlet plus statins on days 2 or 7(p<0.05). The effect of aspirin+clopidogrel+atorvastatin in decreasing MES was better and faster than that of aspirin+clopidogrel. There were no significant differences between TIA and CI (p>0.05). MES was not associated with the risk factors and hs-CPR in patients with cerebral ischemia(p>0.05).Conclusions From the preliminary results combination therepy with clopidogrel, aspirin and statins is more effective than dual antiplatet agents in reducing MES in patients with cerebral ischemia. But the sample capacity is to be increased. MES can be as an index to evaluate the treatment effect. And MES is independent from the risk factors and hs-CRP of ischemic cerebrovascular disorders.