Study On Sensitivity And Drug Resistance Of Antiplatelet Agents In The Treatment Of Acute Cerebral Infarction

ObjectiveTo evaluate the drug sensitivity and drug resistance of aspirin and clopidogrel in the treatment of acute cerebral infarction(ACI)by detecting platelet aggregation function.MethodsA total of 240 patients admitted to our hospital from December 2019 to January2021 were randomly divided into 120 patients(group A)according to different treatment drugs: 300 mg of aspirin per day.120 patients in the double-anti-load group(group B)were given clopidogrel 300 mg combined with aspirin 100 mg on the first day,and aspirin 100 mg plus clopidogrel 75 mg daily on the second day and thereafter.After 14 days of treatment,both groups were switched to aspirin 100 mg/day orally for 3 months.Both groups on the day of admission,7 and 14 days phlebotomize treatment,PL-12 platelet function is used to determine platelet aggregation rate,statistics of two groups of patients and treatment after 14 days prior to admission NIHSS score and MRS scores,records of two groups of patients during hospitalization adverse reactions associated with antiplatelet agents,comprehensive evaluation of two kinds of treatments,To provide a reliable basis for clinical treatment plan.ResultsThere was no significant difference in the general clinical data between the two groups(P > 0.05),but the main NIHSS scores were compared.After 14 days of treatment,the scores of the two groups were significantly decreased compared with before treatment: the NIHSS scores of the double-antibody group were significantly lower than that of the aspirin group after treatment.Comparison of MRS scores at 3months after discharge: the MRS scores of both groups were lower than before treatment,and the MRS scores of the double-antibody group were significantly lower than that of the aspirin group.Under different antiplatelet therapy regimens,the platelet aggregation rate of patients before and after treatment was significantly decreased.The clinical resistance of aspirin was consistent with the biochemical resistance of the maximum platelet aggregation rate.ConclusionsThe effect of aspirin combined with clopidogrel load dual antibody in the treatment of acute cerebral infarction was more significant,and the patients’ NIHSS score decreased before and after treatment in the dual antibody group compared with aspirin monoantibody.Three months after discharge,the MRS score of both groups was lower than before,and the MRS score of the dual antibody group was significantly lower than that of the aspirin group.The data suggest that the platelet aggregation rate can be used to identify patients who are insensitive to aspirin and to guide their clinical treatment.