| Objective:Radioactive skin destruction is a common complication in the radiotherapy of malignant tumor and lack of effective prevention and treatment. Recently, local oxygen therapy was reported to alleviate the anoxia of organ, prove wound healing and delay scar formation. Different flows were used in the oxygen therapy in clinical practice, followed with different curative effect. The most appropriate oxygen flow is still of controversial.The goal of this study is to detect the best oxygen flow in the treatment of radioactive skin destruction.Methods:1.905 patients with head-and-neck cancer or breast cancer received surgery and intensity modulated radiotherapy (IMRT) in Shandong Tumor hospital from December 2008 to December,2010 were recruited in this study They were randomized assigned to 2 groups. They were given normal skin protection measures with (experimental group) or without (control group) local oxygen cure (5-6L/min,30min/time,2times/day). The incidence of radioactive skin destruction and the KPS scores changed after local oxygen cure were recorded. 2.90 patients with head-and-neck cancer or breast cancer received surgery and IMRT in Shandong Tumor hospital from December 2008 to December,2010 were recruited in this study.They were randomized assigned to 3 groups. They were given local oxygen cure with different flows (3L/min,5L/min, 7L/min). The observation index included wound healing rate, healing time, scar formation rate, pain relieving situation, infection rate and KPS scores changed before and after treatment.Results:1.There were no significant difference (P>0.05) in age, sex, location, health education, KPS scores and radiation dose between the control group and the experimental group.2.The incidence of radioactive skin destruction was significantly lower in oxygen cure group than in control group, no significant difference (P>0.05) in KPS scores were found before and after oxygen cure.3. Compared with the low flow (3L/min,5L/min) groups, the wound healing rate was significantly higher (P<0.05), the healing time was shorter (P<0.05) in the High-flow (7L/min) group.4.No case developed bacterial infection in 7L/min group. while two and one did in 3L/min group and 5L/min group. During the follow-up, all radioactive skin destructions were healed but two mild scarring in 3L/min group.5. As to pain relieving, the High-flow (7L/min) group was superior to the low flow (3L/min,5L/min) groups (P<0.05). There was no significant difference between 3L/min and 5L/min group (P< 0.05). No significant difference in KPS scores before and after therapy were found (P> 0.05).Conclusions: Local oxygen cure can effectively delay the occurrence of radioactive dermatitis, prove wound healing, shorten wound healing time, relieve the pain, reduce leakage and infection incidence, especially in High-flow (7L/min) oxygen group. |
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