Treatment Effiency And Effects Of EGF, TNF-a Of Kou Chuang1 About RAU (Accumulated Heat Heart And Spleen Syndrome)

First. PurposeFor the treatment of kouchuang NO.1 (Heart and integrated heat syndrome) patients, and EGF, TNF -a of. With a known effective drug (ZhongTongAn Acpsule) for comparative observation and objective evaluation of the efficacy of drugs for clinical use and development to provide a scientific basis.Second, MethodThe method of this clinical study, randomized, open, male control of the principles of the 23 cases,27 cases of 50 female patients, doctors diagnosed as recurrent oral ulcers, Heart and TCM product is heat syndrome were randomly divided into test group and control group, experimental group and control group 25 cases. Experimental group, kouchuang NO.1 each 100ml,2 times a day; control group was treated ZhongTongAn Acapsule,3 tablets,3 times a day. Were treated for 5 days. Before and five days respectively after treatment referral, observation of major clinical symptoms, signs and symptoms and taking medicine saliva EGF concentration in saliva and TNF-a levels to evaluate the above indicators to compare the experimental group, the efficacy of the control group. Within 3 months of follow subjects observed ulcer recurrence, compared the experimental group, control group long-term effect.Third, the results1. Experimental group of subjects before and after treatment, signs, indicators in the size of ulcer, pseudomembranous ulcers, ulcers congestion, ulcer pain side compared by T test, P<0.05 was statistically significant, the experimental group subjects After treatment, the main symptoms and signs were significantly improved compared with before treatment:2. Syndrome study group before and after treatment in accordance with the scoring criteria of syndrome classification comparison: The T test, P<0.05 was statistically significant, the experimental group Subjects TCM symptoms after treatment than before treatment showed significant improvement.3. Experimental group of subjects before and after treatment EGF concentration in saliva (ng/ml) and TNF-a levels (pg/ml) changed compared by T test, P<0.05 was statistically significant, test after treatment than before treatment showed significant improvement.4. Experimental.group and control group subjects before and after treatment, signs of indicators in the size of ulcer, pseudomembranous ulcers, ulcers congestion, ulcer pain side compared by T test, P<0.05 was statistically significant, the experimental group subjects after treatment The main symptoms and signs with the control group were significantly different.5. Experimental group and control group syndromes before and after treatment in accordance with the scoring criteria of syndrome classification comparison:The T test, P<0.05 was statistically significant, the experimental group subjects TCM symptoms after treatment than before treatment were significantly differences.6. Experimental group and control group subjects after treatment saliva EGF concentration (ng/ml) and TNF-a levels (pg/ml) changed compared by T test, P<0.05 was statistically significant, the experimental group and significant difference between the control group.7. Experimental group and control group in clinical symptoms, TCM clinical efficacy evaluation and the total effective rate comparison:According to criteria of efficacy. The c2 test, test group than the control group. (P<0.05)8. Two groups of subjects and efficient follow-up results 3 months after the relapse rate:, statistical analysis, the relapse rate between the two groups was statistically significant (P<0.05). Experimental group than the control group.Fourth, the conclusionkouchuang NO. 1can significantly improve the recurrent oral ulcers (Heart and heat to permit) the main symptoms and signs of patients, reduce ulcer pain and promote ulcer healing, relieve dry mouth, thirst, urine and other symptoms improve, and still to some extent control the recurrence of ulcers, intermittent episodes of prolonged ulcers can be used in clinical practice.