A Case-control Study On Risk Factors Of Ischemic Stroke

Objective To explore the primary risk factors of ischemic stroke in Tangshan city residents and to ascertain the degree of influence for ischemic stroke of risk factors.To provide the effective control evidence for the prevention of ischemic stroke.Methods The method of 1:1 matched case-control study was conducted.From September 2009 to September 2010,one hundred and sixty patients with acute first ischemic stroke in Affiliated Hospital of Hebei United University were selected as case group;other 160 normal subjects who had no history of stroke were randomly selected as control group.The object of study were selected form Tangshan city permanent residents. All the subjects were surveyed with questionnaires and physical examination ,laboratory parameters including blood-testing results in the first 24 hours at admission. Variance analysis,Chi-squre,nivariate and multivariate conditional logistic analysis were conducted using SPSS 13.0 for window software. The atrbutable risk percentage(ARP) and population risk percentage(PARP) of every risk factor were determind.Results A sample of 160 pairs of cases and controls was studied. Univariate analysis showed that hypertension,cardiopathy,parents'stroke history, diabetes,parents'cardiopathy history, hyperlipidemia,parents'diabetes history, abdominal obesity,smoking,alcohol intake , levels of family income, levels of education, psychosocial stress, vegetables and fruit daily and regular physical activity were related to ischemic stroke. Multiple condition logistic regression analysis showed that hypertension(OR=4.651,95%CI2.833-7.635),cardiopathy(OR=4.250, 95%CI 2.003-9.020),diabetes(OR=2.625, 95%CI 1.359-5.369),hyperlipidemia(OR=1.567,95%CI 1.125-2.014),abdominal obesity(OR=2.701,95%CI 1.121-4.459),smoking(OR=2.082,95%CI 1.292-3.384),alcohol intake (OR=1.410,95%CI 1.092-1.875), psychosocial stres(sOR=1.875, 95%CI 1.007-3.491)were risk factors of ischemic stroke, vegetables and fruit daily(OR=0.545,95%CI0.258-0.78)and regular physical activity(OR=0.756, 95%CI 0.354-0.926)were protective factors of ischemic stroke.The ARP of the ten factors were successively 78.32%,61.19%,76.41%,36.61%,51.29%,29.00%,72.59%,46.26%,43.31%,35.52%,The PARP of the ten factors were successively 56.29%,15.54%,19.76%,15.59%,39.26%,9.41%,46.42%,14.41%,25.76%,12.49%.Conclusion The harmful risk factors responsibal for the development of ischemic stroke in Tangshan city residents are Hypertension,smoking,abdominal obesity, cardiopathy, hyperlipidemia, diabetes, psychosocial stress and alcohol intake .The vegetables and fruit daily and regular physical activity are protective factors of ischemic stroke.