Significance Of Peripheral Blood Serum Thymidine Kinase Determination In Patients With Colorectal Cancer LI Hechun, SHEN

Objective To investigate the diagnostic value of peripheral blood serum thymidine kinase 1 (TK1) in colorectal cancerMethods 1. The serum level of TK1 was determined by enhanced chemi-luminescence assay (ECLA) in 74 patient s with colorectal cancer, and 27 normal cont rols 2. The same 50 cases were detected in patients with advanced colorectal cancer and 40 cases ofⅠ-Ⅲcolorectal cancer patients of the serum TK1 levels.3. also detected 75 cases of colorectal cancer patients after chemotherapy, the serum TK1 levels in peripheral blood, and according to RECIST criteria to determine its clinical efficacy (CR+PR 11 patients; SD 31 patients; PD patients n=33)Results 1. Colorectal cancer STK1 level (2.17±2.29) pmol/L) was significantly higher than the normal control group (0.85±0.48) pmol/L,) (P <0.01).2. Colorectal cancer patients with distant metastasis STK1 significantly higher than that of patients without distant metastasis.3. For treatment of colorectal cancer patients, CR+PR, SD, PD patients STK1 the value of the order of increased disease progression in patients with higher levels of STK1 values, and significantly higher than patients with stable lesions, lesions in stable patients STK1 values than patients with stable disease STK1 is high, and the value of stable disease in patients with low levels of STK1Conclusion STK1 in colorectal cancer screening, diagnosis, distant metastases to determine whether the detected effect, and so has some clinical significance.