An Investigation On Temperature Response And HSP70 Expression Of Photorejuvenation

Laser surgery are playing an increasing role in the treatment of dermatology, such as mottled pigmentation, lentigines, telangiectasias, erythema, rhytides and large pores. Radiant exposure and thermal damage are importantly considered in clinical practice. Also we know that Heat Shock Protein 70(HSP70) is a member of the stress protein family. Hsp70 is high evolutionarily conserved that it plays an essential role in cellular thermotolerance and protection to a broad variety of environmental stressors. The results showed that expression of HSP70 in skin could be used to respond the degree of thermal damage after different laser radiant exposures. Last, Cryogen spray cooling (CSC) has been studied to selectively cool the epidermis during laser treatment. The principle of this method is to spray the skin surface with an appropriately short cryogen spurt immediately before laser exposure so that only the superficial skin layers are cooled while the temperature of the deeper targets remain unchanged. The results showed that CSC permits selectively cool and high heat transfer rates which have possibility of using higher incident fluencies in laser treatment.