The Effect Of Rosuvastatain On Tbe Inflammatory Factor And Endothelial Function Before And After Stents Implantation In Patients With Acute Coronary Syndrome

Objective To investigate the effect of rosuvastatain on the high sensitivity C-reactive protein(hs-CRP)and plasme endothelin-1(ET-1)in patients with acute coronary syndrome(ACS)before and after stents implantation,and evaluate the effect of different doses of rosuvastatain.Methods 60 ACS patients were divided randomly into three groups.20 patie -nts(G1,n=20)were given atorvastatin(Crestor 20mg,qN)for 1 month,20 patients(G2,n=20)were given Rosuvastatain(Crestor 10mg,qN)for 1 month and the rest 20 patients(G3,n=20)were given Rosuvastatain(Crestor 20mg,qN),stents were underwent after three days.Peri -pheral blood samples were drawn to detect the levels of hs-CRP,ET-1 at baseline,24 hours after postope and 1 month after stents implantation respectively and blood lipids,live -r function levels.Results①The levels of hs-CRP with three groups of patients at baseline were no significant difference(P>0.05);the levels of hs-CRP in 24hours after stents implantation were higher than the baseline,groupG1,groupG2 was significantly higher than the groupG3,and statistical difference was significant (P<0.05);the levels of hs-CRP with three groups of patients in 1 month after stents implantation were lower than baseline ,groupG3 was significantly lower than groupG1,groupG2,and the difference was significant (P <0.05);②The levels of ET-1 with three groups of patients at baseline were no significant difference (P> 0.05);the levels of ET-1 levels in 1 month after stents implantation compared to baseline levels were decreased, groupG3 was significantly lower than groupG1,groupG2,and the difference was statistically significant(P<0.05);③The levels of blood lipids(TC,TG and LDL-C) with three groups of patients at baseline were no significant difference(P>0.05);the levels of blood lipids(TC,TG and LDL-C) with three groups of patients decreased in 1 month after stents implantation,groupG3 was significantly lower than the groupG1,and the difference was statistically significant(P<0.05);④The levels of HDL-C with three groups of patients at baseline were no significant difference(P>0.05);the levels of HDL-C levels with three groups of patients decreased in 1 month after stents implantation, groupG3 was significantly lower than groupG1,and the difference was statistically significant(P<0.05);⑤The levels of ALT increased more than 3 times in groupG1,groupG2,groupG3 respectively were 2,1,2 cases;the levels of ALT increased more than 1-3 times in groupG1,groupG2,groupG3 respectively were 5,4,8 cases,Mostly transient,observed two to four weeks back to normal.Conclusion 1.The levels of hs-CRP increased in the 24 hours after stents implantatio -n;2.Rosuvastatin could reduce postoperative inflammation and improve endothelial funct -ion;3.For the same dose,Rosuvastatin 20mg reduce the levels of blood lipid more than atorvastatin 20mg;4.For the same dose,Rosuvastatin 20mg increase the levels of HDL-C more than atorvastatin 20mg;5.Rosuvastatain could reduce inflammatory factor after perc -utaneous coronary intervention and improve endothelial function,which was connected with the doses,it was better in group 20mg than that in the group 10mg.