Investigation Of The Correlation Between The Expression And Pathological Characteristics Of Bmi-1 Protein In Breast Cancer

Purpose:With breast cancer tissue microarray to explore the correlation between the expression and clinicopathological characteristics of Bmi-1 Protein in breast cancer.Methods:tissue microarray was made from 31 specimens of breast cancer and 31 specimens of adjacent tissues; with immunohistochemical technology, the expression of Bmi-1 protein was detected both in breast cancer and adjacent tissues.Results:The expression of Bmi-1 protein in 31 specimens of breast cancer tissues:14 were strong positive (+++),8 were positive (++),4 were weak positive (+), and 5 were negative (-); in adjacent tissues:4 were weak positive (+), and 29 were negative (-). The positive expression rate of Bmi-1 protein in breast cancer tissues was 83.4%, compared with 12.9% in adjacent tissues, the difference was significant (P<0.001). In TNM classification:The positive expression rate of Bmi-1 protein in T1 was 50%,70.0% in T2,88.2% in T3, and 100% in T4. The differences among four stages were significant (P<0.05). The positive expression rate of Bmi-1 protein was 50.0% in N1,81.1% in N2, 100% in N3, and 90.0% in Nx. We compared the stage N2, N3, and Nx with N1 respectively, the differences were all significant (P<0.05, P<0.01).Conclusions:the high expression of Bmi-1 protein plays important roles in the development of breast cancer, and closely correlated with the tumor size and lymph node metastasis of breast cancer. Our study suggests that the expression of Bmi-1 protein may be a novel marker in breast cancer's diagnosis and prognosis.