Evaluation On The Risk Factors Of Re-fracture In Elderly Osteoporosis Patients

Objective: To evaluate the risk factors of re-fracture in elderly osteoporosis patients, revealing the distribution of these risk factors, for early and accurate prediction the secondary osteoporotic fractures and provide an objective basis. then giving the appropriate interventions to prevent re-fracture occur. Methods: This article adopt retrospective case-control study, retrospective case-control study, cases selected from the Guangzhou Medical College, Guangzhou First People's Hospital of Orthopedics January 2007 ~ March 2011 period, due to osteoporotic fractures in hospitalized patients, randomly selected 60 patients for cases and control group , 22 variables were investigated including age, sex, body mass index (BMI), bone mineral density T values, anti-osteoporosis treatment history, family history, application of glucocorticoid drugs, treatment programs, the incidence of the season, incentives, concurrent A variety of medical diseases and the daily life style and habits,etc.。the use of SPSS17.0 Edition software package, using chi-square test, univariate analysis of variance, binary logistic regression analysis method, the use of chi-square test, ANOVA, binary logistic regression analysis method, First analysis of the case group, compared the incidence characteristics with the twice osteoporotic fractures; further comparative analysis of case and control groups, identification and testing the relationship between these factors and secondary osteoporotic fracture.Results:1,Group of 60 cases of descriptive statistical analysis showed that: predisposing factors of the first and second osteoporotic fractures was no significant difference, falls are the main reason for osteoporotic fractures (80.0%); Spine and hip fractures are the main site of the twice fractures. The incidence seasons of twice fractures are mostly in the winter and spring. Whether anti-osteoporosis therapy on the twice fracture interval had significant effects.The twice fracture interval of patients with anti-osteoporosis treatment was longer than the patients with non-anti-osteoporosis therapy; The average of interval between two fractures ware 14.27 months. Time distribution was biased normal distribution.2,After the case group and control group chi-square test and ANOVA showed that there are 12 significant factors of the incidence of secondary osteoporotic fractures, including age, bone mineral density T values, anti-osteoporosis treatment, corticosteroids, Drugs, hypertension, diabetes, cerebrovascular disease, chronic bone and joint disease, and live alone, outdoor activities, smoking, ofen drink milk.3,Using SPSS17.0 package, the above factors by logistic regression analysis selected five main risk factors cause the second osteoporotic fracture, including age, bone mineral density T value, cerebrovascular disease, diabetes, and live alone. 2 minor risk factors include hypertension, corticosteroid drugs; one major protective factor is anti-osteoporosis treatment; often dink milk is secondary protective factors, also exclude other possible confounding factors, including Chronic bone and joint disease, outdoor activities, smoking, etc.;Conclusion:The survey found that five factors including age, bone mineral density T values, diabetes, cerebrovascular disease, and live alone are major risk factors of secondary osteoporotic fracture; hypertension, corticosteroid drugs may be the minor risk factors; resistance Osteoporosis treatment, often dink milk may be the protective factors; analysis of the case group reached: the spine and hip are multiple sites of secondary osteoporotic fracture; Predisposing factors are mainly falls, Incidence season are mainly winter and spring, Anti-osteoporosis therapy can significantly delay the time of re-fracture;Interval between two fractures are partial normal distribution, the average interval is 14.27 months.