The Expression Of The HRG-1 Gene In Bladder Cell Carcinoma And Normal Bladder Tissue

Bladder cancer carcinoma(BCC) is one of the most common body tumors, accounting for 3.2% of all malignancies. It ranks No.1 in all urological cancers. Transitional cell carcinoma accounted for 90% in all BCC[ 1] ,while squamous cell carcinoma accounts for 2.5% and adenocarcinoma accounted for the rest 1.6%.Epidemiological inverstigation reveals that its incidence increase year by year, with its genuine cause remain unclear. Hemoglobin gene 1 (heme-responsive gene 1, HRG-1) was officially named in 2008. It locates on chromosome 12 (12q13.11). In our previous studies with DU-145 prostate cancer cell, we found that pcar has 78% homology with HRC-1, and it is functional related with cell apoptosis. Though we found that HRC-1 has a significant relationship with prostate cancer, no previous reports has hinted any possible relation between HRG-1 and bladder cancer pathological grade and clinical stage. Therefore, in this study, we tried to find out whether the bladder HRG-1 overexpress in bladder cancer, and whether it correlates with bladder cancer clinical stage and pathological grade. Purpose To observe HRG-1 gene expression in the carcinoma of urinary bladder and normal urinary bladder tissues, and to explore the relationship between HRG-1 gene expression and bladder tumor pathologic stage and the clinical stages.Methods Immunohistochemistry was used to detect the expression of HRG-1 in bladder cancers (63 cases) and normal bladder tissues (28cases).Results HRG-1 gene expression has significant differences between the bladder cancer and normal bladder tissues (p<0.05); HRG-1 gene overexpression was significantly correlated with bladder cancer's pathological grading and clinical stages (p<0.05).Conclusions The overexpression of HRG-1 gene may play the important roles in bladder cancer, and it may be a valuable indicators of bladder cancer's pathological grades and clinical stages.