HnRNP K Expression In Transitional Cell Carcinoma Of Bladder And Its Clinical Significance

Objective: By investigating the expression of hnRNP K in transitional cell carcinoma of bladder (BUCC), we approach the relation between hnRNP K expression and pathological grades, clinical stages, and recurrence/metastasis to discuss the potential clinicopathological significance of hnRNP K expression in transitional cell carcinoma of bladder.Method: Immunohistochemistry (SABC) was used to detect the expression of hnRNP K in 60 tissues of transitional cell carcinoma of bladder and 10 tissues of normal bladder. With clinic pathological characters and follow-up information, we analysized the correlation between the hnRNP K expression and pathological grades, clinical stages , recurrence/metastasis and prognosis of BUCC.Results:1. The proportion of hnRNP K positive expression in the normal group was 20.0% (2/10); while in BUCC group is 61.7%(37/60). There is statistical significance of the hnRNP K difference expression between the two groups (p<0.05) .2. hnRNP K expression in BUCC tissues was significantly related to pathological grades (p<0.05) .3. Although there was not significant differences of hnRNP K expression in Ta-T1 stage and T2 stage (p=0.495) , in general, hnRNP K expression in BUCC tissues was related to the clinical stages.4. hnRNP K expression in BUCC tissues has no significant relationship with age, size or quantity of mass.5. There was significant differences between incipient and recurrence BUCC tissues, and the postoperative follow-up showed that The hnRNP K expression was significantly related to survival time and recurrence/metastasis of patients with BUCC (p<0.05) .Conclusions: The expression of hnRNP K closely correlated with the clinical stages and pathological grades of BUCC, the risk of recurrence/metastasis and the prognosis of BUCC. hnRNP K may play an important role in the process of invasiveness and metastasis of BUCC. hnRNP K may be of great value in predicting the prognosis of patients with BUCC.