The Clinicopathological Trichoepithelioma Analysis

Objective: To discuss the clinicopathological feature of patients with trichoepithelioma, and in order to provid scientific proofs of prevention and cure of trichoepithelioma.Methods: We collected 18 cases clinical data and pathological specimens of trichoepithelioma patients which they had been final diagnosised by our hospital from 2000 to 2010 year, There were 7 males and 11 femals with the duration from 6 month to 58 years. The age of onset was from 15 to 58 years. All the specimen was fixed in 4% formaldehyde solution, general organization dehydrated, embedded in paraffin, sliced, hematoxylin eosin staining. Through comprehensive analysis of the characteristics of pathological changes and clinical.Result:In the 18 cases of trichoepithelioma patients, which were 7 males(38.9%)and 13 femals (61.1%), ranging in age from 6 month to 58 years, The average age of onset was 37.2 years. All cases presented as papules or nodules, in the most patients there is no the subjective symptoms. In 10 patients of multiple lesions, predominantely on the nasolabial folds, manipulus involve lower eyelid or neck, In 8 patients of multiple lesions, respectively distributed on nasal ala and nasal dorsum.The multiple trichoepithelioma usually emerged erythra at childhood or youth, presented yellow or jasmine hemispheroid papulae, diameter from 0.2 to 0.5 centimeter. Histopathologic change showed mainly that basal cell-like cells hyperplasia and the cells differentiated to hair follicle and sebaceous gland ducts. Pathological changes are mainly basal cell-like cell proliferation, differentiation to the hair follicles and sebaceous ducts, showing that the majority of basal-like cells set into the fence like arrangement around the nucleus, around the obvious fibrous matrix and fibroblasts in the connective tissue and sometimes visible between the cracks, there are many dermal papilla-like structure and the angle of cysts, and sometimes can be found in the keratinized tissue calcification. Clinically misdiagnosed as moles, syringoma, basal cell carcinoma. The 8 cases solitary trichoepithelioma were to be cut by esthetic surgery, following up 1 year,7 casee no recurrence,1 case secondaried squamous cell carcinoma.The 10 cases multiple trichoepithelioma were to be treated by hyper- pulse carbon dioxide lasers, following up 1 year, no tendency of cicatrix, recurrence and canceration.Conclusion:①The solitary trichoepithelioma was diameter 0.5 centimeter and hard to final diagnosis depending on clinical manifestation. The multiple trichoepithelioma was relate to genetic factor, it was diameter 0.2-0.5 centimeter, inequality of size node and predilection two sides of nasolabial fold,which was be final diagnosis by family history and histopathology.②The area patients of trichoepithelioma can be treatmented by methods of lasers, operation and so on.