| The relationship between inflammation and acute coronary syndrome (ACS) is gaining more and more attention at the present time. The acute coronary events are closely related to plaque rupture and thrombosis, and inflammation may be an important trigger mechanism. Recently, foreign studies on RDW as the evaluation of heart failure and cardiovascular events as well as prognostic factors have been given great concern. However, such clinical research are rare in China. This paper is focused on the relationship between RDW and ACS through case analysis and evaluates the significance of RDW in the assessment of ACS patients.Objective:to explore the relationship between RDW and ACS, and to further evaluate the changes of RDW in ACS patients and its clinical significance.Methods:135 patients with acute coronary syndrome (ACS group) admitted into Department of Cardiology, China-Japan Friendship Hospital, Jilin University from March,2009 to January,2011, were chosen in this study; at the same time, fifty patients who weren't diagnosed of ACS by coronal artery angiography were chosen as the control group. Both groups were subject to blood routine test and biochemical measurement of RBC, Hb, RDW, blood lipids, uric acid and CRP; cardiac color ultrasound scanning was given to all the selected patients to measure their LVEDD and LVEF; troponin test was given to ACS group; all patients were subject to coronal artery angiography and the Gensini scoring system measurements. The statistical analyses were performed using SPSS-13.0, and the comparison of measurement data of the two groups were conducted with t test; the comparison of enumeration data of the two groups were conducted with chi-square test. The correlation analysis of data was performed using linear correlation and regression analysis. The differences in age, sex, the content of blood lipid and uric acid, CRP, RDW, RBC, Hb, cTn I, and LVEF of the two groups were compared using the above statistical methods. The relationship between RDW and ACS within groups and the correlation between RDW and LVEF and C-reactive protein, respectively, were further analyzed.Results:1. In comparison with the control group, LVED of the ACS group were higher (P< 0.05); RDW and CRP of the ACS group were significantly higher (P<0.01), while LVEF was significantly lower (P<0.05). All of these were of statistically significance. 2. In the within-group comparison of the ACS group, RDW of AMI group was higher than that of UA group (P<0.05); CRP and cTNI of AMI group were significantly higher than those of UA group (P<0.01). The relationship between RDW and cardiac function showed that the RDW of groups with LVEF less than 35% were higher than that of the normal group (P<0.01).3. The linear regression analysis indicated that RDW of the patients in AMI groups had a positive correlation with C-reactive protein (r=0.438)Conclusions: 1. RDW of ACS group was significantly higher than that of the control group, and that ofthe AMI group was significantly higher than that of the UA group.Combined with the current domestic and foreign research. Therefore,RDW can be used as an objective, secondary and convenient index in the clinical evaluation of risk stratification of cardiovascular events.2. RDW was correlated with C-reactive protein, and this may be a marker of the level of inflammation.3. RDW increased significantly with the decline of EF value, and it was correlated with the cardiac function. It may be used as a predictor to heart failure in patients with coronary heart disease. |
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