The Effects Of Bone-building Exercise On Bone Mass In Postmenopausal Women With One Year's

Objective: By observing the changes of bone mineral density (BMD), bone mineral content (BMC), body composition, muscle strength of waist and hip, and biochemical markers of bone metabolism before and after one year's bone-building exercise in postmenopausal women, to explore effection of exercise on bone mass and examine the effectiveness of bone-building exercise program. Meantime, this study can provide experimental basis of reasonable exercise prescription, aiming to prevent and improve osteopenia or osteoporosis in postmenopausal women.Methods: 63 postmenopausal (>3 ys, without endocrine diseases) women who were screened from 50 communities in Beijing, with no medication or illness affecting bone metabolism, were randomly assigned to two groups: the Exercise Group (EG), which comprised of 32 subjects, participated in bone-building exercise; and the Control Group (CG), which consisted of 31 subjects. Relevant indexes were measured and analyzed at baseline, 6 months, and one year's after exercise respectively. BMD, BMC and body composition was measured by dual-energy x-ray absorptiometry (Lunar Prodidy, GE, USA). Isokinetic muscle strength of waist and hip were measured by isomed2000 Basic System and Back System (DR Ferstl GmbH, Germany). Biochemical markers of bone metabolism, including BGP, BAP, 25-OH-VD, TRACP-5b, were detected by ELISA (Thermo S200, American). All data were analyzed using SPSS 13.0 statistical software. Descriptive index were reported as means and standard deviation (means±SD). Differences within and between groups were assessed with One-Way ANOVA; Correlation analysis were assessed with pearson correlation. During experiment, participants in this study had accident insurance by investigator and signed a written informed consent.Results: After one year's experiment, EG had no remarkably diference in weight and F% compared with before experiment,however, there had a decreasing trend. After year's experiment,compare to before experiment in CG,there were no remarkable difference in weight and F%. However, there had a rising trend. Bone-building exercise after one year's experiment , change percentages of BMD of right femoral neck and proximal femur in EG were higher than that in CG (p<0.05); BMC of right femoral neck in EG were higher than that in CG (p<0.01). After one year's experiment, BAP in EG were higher than that in CG (p<0.05). Bone-building exercise at 6-month, 25-OH-VD in EG increased significantly compared with baseline (p<0.05). After one year's experiment, BAP was observably higher in EG than baseline (p<0.01), and BAP in EG were observably higher than 6-month (p<0.01), while TRACP-5b in EG and CG were significantly increased, compared with baseline (p<0.01). After one year's experiment, muscle strength of waist and hip in EG had observably elevated, compared with baseline (p<0.01).Conclusions: By bone-building exercise after one year's experiment,weight and F% in EG had a decreasing trend.The integrity of the whole muscle strength in EG were enhanced. It showed that bone-building exercise could make bone metabolism vigorously.Meanwhile, the biochemical marker's level standard of bone formation were in elevation level predominantly in EG.,while the biochemical marker's level standard of bone resorption were in elevation level predominantly in CG.In EG, the variance ratio of bone mass in femur neck and proximal femur was higher than CG which was remarkable as well as bone-building effect. Summarizing we may state that the change of bone mass in EG is closely related to rationality of bone-building exercises plan.