The Study On The TCM Syndrome Character Of Early Renal Damage In Hypertension

Objective:To observe the laboratory index of early renal damage in hypertension patients, and to explore the correlation with the TCM syndrome differentiation.Method:Patients aged from 18-80 were chosen from inpatient and outpatient department which were diagnosed as phaseⅡandⅡhypertension according to the hypertension diagnostic standard,and the phaseⅡpatients is the main observed object.We performed syndrome differentiation according to the clinical symptom and physical sign,observed the blood pressure, heart rate and the laboratory index of early renal damage:Urine MAlb,β2-MG and NAG.All data were collected and statistical analysis of the data was performed by SPSS 17.0 software.Results:There are all significant difference in urineβ2-MG between 4 groups(P<0.05), the hyperactivity of liver fire group is the highest, the accumulation of phlegm and dampness group is the second,and Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group is the lowest.There are significant difference in urine MAlb between the hyperactivity of liver fire group and the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P<0.05).There are significant difference in urine MAlb between the accumulation of phlegm and dampness group and the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P<0.05).There is no significant difference between the hyperactivity of liver fire group and the accumulation of phlegm and dampness group(P>0.05).There is no significant difference between the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P>0,05).the accumulation of phlegm and dampness group is the highest, the hyperactivity of liver fire group is the second,and Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group is the lowest.There are significant difference in urine NAG between the hyperactivity of liver fire group and the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P<0.05).There are significant difference in urine NAG between the accumulation of phlegm and dampness group and the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P<0.05).There is no significant difference between the hyperactivity of liver fire group and the accumulation of phlegm and dampness group(P>0.05).There is no significant difference between the Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group(P>0,05). the hyperactivity of liver fire group is the highest, the accumulation of phlegm and dampness group is the second,and Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group is the lowest.Conclusiom:there is different extent of abnormal in the laboratory index of early renal damage in all types of hypertension patients, and significant elevation in hyperactivity of liver fire and accumulation of phlegm and dampness groups,which indicates that the obvious impairment of the filtration of renal tubular and glomerular filtration rate,and there are both impairment in filtration membrane selective electrical barrier and screen barrier,while there is only slight impairment of renal tubular in Yin deficiency with Yang hyperactivity group and Yin-Yang deficiency group.The common rule of TCM syndrome of early renal damage in hypertension patients is that the liver fire hyperactivity syndrome is the worst,accumulation of phlegm and dampness is in second place, and that of the Yin deficiency with Yang hyperactivity and Yin-Yang deficiency is the lowest,which indicates that the main syndrome is the excessive syndrome and the mixture of excessive and deficiency syndrome, and the pathological change is related with the increase of renal vessel resistance.