The Clinical Observation On Treating Chronic Kidney Disease 3 Period Patients By Shen Shuai Ⅰ Hao With Spleen And Kidney Qi Deficiency And Wet Stasis

Objectives:To evaluate the clinical effect of Shen Shuai I Hao on treating chronic kidney disease 3 period patients with spleen and kidney qi deficiency and wet stasis.Methods:60 patients with spleen and kidney qi deficiency and wet stasis of chronic kidney disease(CKD) 3 period who were treated in jiangsu provincial TCM Hospital were choosed and divided into two groups.One group was the observing group,40 patients of which were treated with Shen Shuai I Hao,two times one day and routine western medicine.The other group was the control group,with 20 patients being treated with only routine western medicine. 30 days is a therapeutic phase.Both groups were treated for 3 phase consecutively.Compare the differences of RBC,Hb,BUN,Scr,UA,eGFR and clinical symptom scores between the two groups before and after observation.Results:(1)the total effect:In 40 patients of the observing group,the number of the significantly effective case is 11,the effective is 20, the stable is 8,the invalid is l,the observing group total effective rate was77.5%;the number of the significantly effective case is 2,the effective is 5,the stable is 8,the invalid is 5.The effective rate from the treatment group is clearly superior(P<0.01).(2)the impact of physical and chemical indicators:After treatment,BUN and Scr of the observing group is significantly lower than before(P<0.01),the eGFR is significanthlty higher than before(P<0.01).BUN,Scr and eGFR of the control group are all not obvious difference,before and after treatment(P>0.05).The observing group can reduce BUN,Scr,increase eGFR,and more effective than the control group(P<0.05orP<0.01).And there was no difference in the effects of Alb,RBC and Hb between the two groups(P>0.05).(3)the syndrome impact:the total score of syndrome improvement of the observing group is better than the control group (P<0.01). After treatment,the score of the syndromes such as weak burnout,shortness of breath,lazy introduction,anorexia,waist and knee flaccid,limb heavy storm,dry mouth,lumbago is lower than before(P<0.01 or P<0.05).The effect of clinical symptoms such as the weak burnout, anorexia,waist and knee flaccid,dry mouth were better than control group(P<0.01 or P<0.05).Conclusions:Shen Shuai I Hao can improve the clinical symptoms.The total effect of treating with it and routine western medicine is obviously better than treating with pure routine western medicine.It can improve the clinical symptoms such as the weak burnout,shortness of breath,lazy introduction,limb heavy storm,waist and knee flaccid,lumbago and dry mouth;reduce BUN,Scr,increase eGFR,thereby slow down the progress of the chronic kidney disease course.