Analysis Of Popular Features And The Risk Factors For Deep Nosocomial Fungal Infection In Affiliated Hospital Of Ningxia Medical University From 2004 To 2008

Objective To explore the popular features and the risk factors for deep nosocomial fungal infection in Affiliated Hospital Of Ningxia Medical University from 2004 to 2008.Methods The clinical data of Inpatients with deep nosocomial fungal infection in Affiliated Hospital Of Ningxia Medical University from 2004 to 2008 were retrospectively investigated and analyzed,mainly on the the total number of specimens,the trends of deep nosocomial fungal infection in nearly 5 years,the source of fungal specimens,the types and changes of speciments,the departments,the drug sensitivity and the treatment.The risk factors for deep nosocomial fungal infection were analyzed by logistic regressive analysis.Results 1. The popular features for deep nosocomial fungal infection in nearly 5 years:①The total number and the constituent ratio of deep nosocomial fungal infection had risen clealy;②The main pathogens of deep nosocomial fungal infection were candida albicans,but the distribution of types had changed, non‐Candida albicans is going to replace candida albicans;③Disease of respiratory is the most common diseases,and malignant solid tumors is the most common disease;④Deep nosocomial fungal infection occurred mainly in respiratory tract and urinary tract ;⑤The center ICU is the most common department for deep nosocomial fungal infection;⑥The rate of drug‐resistance to azoles had risen clealy. 2.The logistic regressive analysis showed that combined application of antimicrobial,TPN, artificial mechanical ventilation and age≥60 were the main risk factors for deep nosocomial fungal infection,empiric therapy is the protective factor.Conclusions The overview of deep nosocomial fungal infection was increasingly serious in nearly 5 years , the distribution of deep nosocomial fungal infection had changed, the rate of sensitive to azoles had went down. Combined application of antimicrobial,TPN, artificial mechanical ventilation and age≥60 were the main risk factors for deep nosocomial fungal infection,empiric therapy is the protective factor.