The Clinical Research On The Treatment Of Tonifying Kidney And Activating Blood To Recurrent Spontaneous Abortion Caused By The Shortage Of Blocking Antibodies

Object:In clinical observation, about 40%-60%of unknown etiology in patients with recurrent spontaneous abortion, is particularly important immune factors, the traditional Chinese medicine turned around common type of kidney deficiency and blood stasis in order to permit the corresponding square method, the proposed treatment of Nourishing the kidney and Removing the blood stasis to recurrent spontaneous abortion with low antibody closed to observe the effect, through the research we expect to scientifically and objectively evaluate the clinical efficacy, establish and improve medical treatment of blocking antibody in recurrent spontaneous abortion lower efficacy standards.Methods:Recurrent miscarriage lower blocking antibodies (RSA) 60 patients,60 patients were completely randomized into Chinese Medicine and Western medicine group.In Chinese medicine group, medicine to kidney blood is Nourishing the kidney and Removing the blood stasis, medicinal Shu Di 10g, Dang Gui 10g, Shan YuroulOg, Bai Shao 10g, Xian Lingpi 10g, Tu Sizi 10g, Chuan Xiong 6g, Dan Shen 10g, Ji Xueteng 15g (made into granules, by Jiang Yin Tianjiang Pharmaceutical Co. Ltd.), one dose a day, morning and evening hours twice a blunt Continuous treatment for 3 months for a course of treatment. Treatment of 2 courses., menstrual cramps, stop taking, follow-up services via the net. Western group were spouses of patients with cubital vein, anticoagulation, conventional separation, concentrated extract lymphocytes, washed clean after use 9g/LNaCl solution was diluted to living cells> 3×107/L. The deltoid muscle in the forearm of patients at the hypodermic injection within 3 points, a total of 1mL.1 every 3 weeks,4 times for a course of treatment. Treatment of 2 courses. Treatment 3 months later blocking antibody.Results:(1) blocking antibodies:Western group and the TCM group before treatment anti CD3-BE, anti-CD4-BE, anti-CD8-BE-negative situation between the two groups, P> 0.05, no significant difference. After treatment, the blocking antibody significantly improved compared with before treatment, but between the two groups blocking antibodies against CD3-BE, anti-CD4-BE, anti-CD8-BE positive the situation in the comparison, P> 0.05, no significant differences, indicating that Chinese group Of the RSA role of blocking antibodies in patients with active immunotherapy treatment group was no significant difference.Efficiency of Blocking blocking antibodies:Western group and TCM group closed anti-CD3-BE efficiency before and after treatment, P<0.05, that Western group and the TCM group the efficiency of anti-CD3-BE closed before and after treatment were significantly different; treatment group And Practitioners efficiency of anti-CD4-BE closed, the efficiency of anti-CD8-BE closed before and after treatment, P> 0.05, that Western group and the TCM group the efficiency of anti-CD4-BE closed, anti-CD8-BE efficiency before and after treatment were not closed Significant difference. Between the two groups before and after treatment of anti-CD3-BE closed the efficiency of a closed anti-CD4-BE efficiency, the efficiency of anti-CD8-BE closed to change the comparison, P> 0.05, that between the two groups before and after treatment of anti-CD3-BE closed efficiency Anti-CD4-BE closed efficiency, the efficiency of anti-CD8-BE closed there was no significant difference in the change.(2) symptom scores:two points in each group and the total score of symptoms before and after treatment comparison, P values were less than 0.05, so both groups, the symptom score and total score before and after treatment were significantly different. Between the two groups at the waist and knees, dizziness, tinnitus, depression, insomnia, fatigue, weakness, menstrual symptoms and color quality, and the results compared before and after treatment, P> 0.05, so the two groups in changes in waist and knees, dizziness, tinnitus, depression, insomnia, fatigue, weakness, menstrual symptoms on color quality were not significantly different; two groups in the tongue, pulse, symptoms, and compared the results before and after treatment, P<0.05, so the two groups in changes in tongue, pulse, there were significant differences in symptoms, Chinese medicine Western group improved significantly compared with this symptom. Total score between the two groups on the symptom before and after treatment comparison, P<0.05, so the total score of two groups of symptoms were significantly different before and after treatment, improvement of symptoms in traditional Chinese medicine group was significantly higher than Western medicine, that will enhance RSA Invigorating Kidney symptoms in patients with kidney deficiency and blood stasis.(3) treatment group and the total effective rate of Chinese Medicine are:76.7% and 90%. Comprehensive Comparison of the efficacy of the two groups, P> 0.05, no significant difference.Conclusion:Kidney deficiency and blood stasis is the type of blocking antibodies lower the importance of recurrent spontaneous abortion pathogenesis, Nourishing the kidney and Removing the blood stasis is the low-type blocking antibody treatment of recurrent spontaneous abortion important treatment method:Nourishing the kidney and Removing the blood stasis medicine adjustable low-type recurrence of blocking antibody Of blocking antibodies in patients with spontaneous abortion, and promote the improvement of antibody to improve the symptoms in patients with kidney deficiency and blood stasis.