The Clinical Study Is About The Research Of Efficacy For Treating Diabetic Peripheral Neuropathy (DPN) With Tonifying Qi Huoxue Away Bi-complex Soup

Purpose:Discuss TCM in diabetic peripheral neuropathy understanding adopt tonifying qi huoxue soup in the treatment of diabetes extinction polio-free,peripheral neuropathy and blood stasis syndrome.Through randomized controlled trials,observe tonifying qi huoxue soup to eliminate bi-complex diabetic peripheral neuropathy and blood stasis syndrome patients blood glucose,blood fat and glycated hemoglobin,hemorheology,nerve conduction velocity,nitric oxide(NO), superoxide dismutase (SOD),discusses the prevention and cure disease mechanism.Methods:Using random parallel comparison research method, will meet diabetic peripheral neuropathy and blood stasis syndrome diagnosis standard patients,randomly divided into treatment group and control group.In lifestyle intervention and western medicine,on the basis of conventional treatment group to oral happy (IP method widely pancreatic peptide enzyme enteric-coated metformin hydrochloride) treatment,the treatment group wide with pledge to happy (oral pancreatic shock peptide enzyme enteric-coated metformin hydrochloride) combined with traditional Chinese medicine water decoction tonifying qi huoxue soup of extinction,oral treatment polio-free,four weeks of treatment for 1 observe 2 treatment.Both groups were evaluation before and after the treatment of its clinical symptoms and signs before and after the treatment of change,blood sugar,blood fat,observed glycosylated hemoglobin,hemorheology, electromyography, nerve conduction velocity, nitric oxide, superoxide dismutase (sod), lower limb artery pa and the patient's such indicators as adverse reactions, compliance. All data to SPSS17.0 statistical software for statistical analysis.Results:Diagnose and incorporate of peripheral neuropathy in diabetes and blood stasis syndrome patients 60 patients (30 cases in treatment group and control group,30 cases), before treatment two group of gender, age, duration, etc baseline data by statistical processing non-significance difference, comparable.①For signs and symptoms improved:treatment group patients after treatment, the symptoms were obviously improved, with the total effective rate of 93.33%, the comparison group total effectiveness for 60.00%. TCM symptoms improved conditions in treatment group than in control group (P<0.05).②Hypoglycemic effect: treatment group patients fasting blood glucose, blood sugar,2-hr glycosylated hemoglobin ale control and patients are relatively before treatment significantly (P<0.01), the control group patients fasting blood glucose, blood sugar 2-hr than before treatment have difference (P<0.05). The treatment group patients fasting blood glucose, blood sugar,2-hr glycosylated hemoglobin improvement is group compared with difference (P<0.05).③Hemorheology:after treatment, the two groups of whole blood viscosity (high cutting, cut, low shear), plasma viscosity which is before treatment decreased obviously (P<0.01). The treatment group whole blood viscosity (high cutting, cut, low shear) improve a group compared with difference (P<0.05), but the two groups after the treatment of plasma viscosity improve no obvious difference (P>0.05).④Emg: treatment group patients with bilateral peroneal motor nerve, sensory nerve conduction velocity, amplitude are relatively before treatment improved significantly (P<0.01), The control group patients peroneal nerve, right movement sensory nerve conduction velocity is before treatment improved significantly (P<0.01), left the peroneal sensory nerve volatility is before treatment improved significantly (P<0.01), but more than on improvement are not obvious (P>0.05). Comparison between groups, the treatment group patients with bilateral peroneal motor nerve, sensory nerve conduction velocity, amplitude improvement are superior to that of the control group (P<0.05 or P< 0.01).⑤Serum levels of nitric oxide and superoxide dismutase (SOD): two groups of patients after treatment, serum aubject, SOD indexes than before treatment improved significantly (P<0.01), Contrast between groups, the curative effect of treatment group was significantly better than control group (P< 0.01).⑥Lipid before and after the treatment effect:two groups patients total cholesterol (TC), triglycerides (TC), high-density lipoprotein (hdl-c), low-density lipoprotein (LDL)-C) were not significantly difference (P> 0.05), between groups comparisons are no obvious difference (P> 0.05).⑦Liver and kidney function checks are in the normal range. Both groups has not seen the adverse reactions.Conclusion:From the preliminary clinical research perspective, tonifying qi huoxue soup can not only improve away bi-complex diabetic peripheral neuropathy and blood stasis syndrome the clinical symptoms, reducing blood sugar, lipid, still can improve hemodynamics and slowing in vivo oxidatie stress reaction, alleviate nerve endometrial vasodilation barriers, improve nerve conduction velocity, and safe and effective, and it has a broad prospect of application, deserves further study.